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29 Cards in this Set
- Front
- Back
- 3rd side (hint)
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describe the hepatobiliary/exocrine pancreatic structure
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largest visceral organ
glissons capsul falciform ligament lobes |
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describe the hepatic circulation
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hepatic artery
portal vein |
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portal vein and oxygen
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imcompletely saturated
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hepatic lobules
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functional units of liver
organized around a vein empty>hepatic vein>sup VCava plates seperated by sinusoids |
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cell structure of hepatic lobules
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endothelial
kupffers lobules bile see slide 3 for more details |
Lobules--are the functional units of the liver organized around a central vein. Bile ducts on periphery of lobules. Kupffer cells are reticuloendothelial cells that are capable of removing and phagocytizing old and defective blood cells , bacteria and other foreign material from the portal blood as it flows thru the sinusoid. Bile Canaliculi, lie between the cell membrances of adjacent hepatocytes. Bile is produced in the hepatocytes and then moved into canaliculi. |
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kupffers cells
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reticuloendothelial cells
remove/phag old blood cells, bacteria, foreign matter from blood |
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lobules
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supplied by bile channels that lie between cell membranes
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bile
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produced by hepatocytes
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flow of bile
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to caniculi>larger ducts>right and left hepatic duct
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endothelial cells _____ substances
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exchange
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metabolic functions of liver
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prod: bile, urea, glycogen, clot factors, plasma protein,
metab: adrenal hormone, drugs, protein, lipid, storage: glycogen, blood, vitamins, minerals excrete: bile, cholest phago, detox |
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which proteins do the liver synthesize
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albumin
fibrinogen clotting factors amino acid transamination |
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someone with liver disease general assessment
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weakness, fatigue, anorexia, weight loss, muscle waisting
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someone with liver disease temperature
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fever
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someone with liver disease skin assessment
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bruising, bleeding, palmar erythemia, petechia, spider angioma
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someone with liver disease blood and vascular assessment
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blood/vasc: irregular menses, impotence, widened pulse pressure, tachycardia, vasodilation, hyper/hypoglycemia, hypocalcemia, hypercholesterolemia, anemia
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someone with liver disease fluid assessment
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ascited, periphreal edema
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someone with liver disease liver and spleen assessment
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enlarged
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someone with liver disease esophagus assessment
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esophageal varices
extremely dilated sub-mucosal veins in the lower esophagus. |
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liver and carbohydrate metabolism
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stores glycogen
makes glucose converts CHO to fat |
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albumin function
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plasma colloidal osmotic pressure
binding/transport substances like drugs, hormones, fatty acids, bilirubin |
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oxidation deamination
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removal of amino groups from AA and conversion of AA to ketoacids/ammonia
ammonia eliminated in form of urea by kidneys |
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lipid metabolism in liver
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oxidation of FA for energy
makes cholesterol, phospholipids, lipoproteins, makes triglycerides from CHO and proteins |
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HMG COA inhibitors are aka
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statin drugs.
stops production of cholesterol in the liver |
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bile
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emulsifying fats
formed from cholesterol 94% are reabsorbed in distal ileum excreted in feces |
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bile flow impediments
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cholestasis
decrease bile flow reduces secretion of H2O, bili and bile materials accumulate in blood causing intrinsic liver disease |
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whose bile function becomes impeded
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native americans
european cauca obese those who loose weight rappidly cys fibrosis sickle cell |
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whose bile function is not impeded
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american caucasions
asains |
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disorders of the small canaliculi and bile duct
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primary biliary cirrhosis
primary sclerosing cholangitis genetic disorders |
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