S6 Week 4 Pharmacology

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PLC=phospholipase C; DAG=diacylglycerol

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Sodium depletion can result in hyponatremia …an increase in Li reabsorption can push plasma levels into toxic range
Sweating (heavy) without appropriate rehydration can increase Li levels
Excessive salt intake can increase Li clearance, decreasing plasma levels
Suggestion: review HB1 before boards if you forgot TI…Li has narrow TI…drugs with narrow TI require monitoring of dose & careful watch on any drugs or conditions that might increase plasma levels.

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