S5 Week 2 Pharmacology

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Steroids for IL-1 and NSAID’s for prostaglandins

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Allopurinol: Reduced uric acid production by inhibiting xanthine oxidase; leading to increased amounts of more soluble xanthine and hypoxanthine. Cannot be given with probenecid, as it inhibits it's metabolism.

Probenicid: A uricosuric drug used to increase urinary excretion of uric acid; affects transporters in the proximal tubule.
Used to decrease tophus deposits in patients who undersecrete uric acid.

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corticosteroids
What enzyme gets inhibited to reduce arachidonic acid (AA) levels? Phospholipase A

B. NSAIDs
Do both drugs at A & B inhibit prostaglandin production. Answer: YES
What about leukotriene production? Corticosteroids reduce leukotrienes but NSAIDs increase precursors that produce leukotrienes so NSAIDs can shift toward greater leukotriene production.

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