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18 Cards in this Set
- Front
- Back
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324. Pathophysiology of Histiocytosis X?
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a. Chronic interstitial pneumonia caused by abnormal proliferation of histiocytes (related to Langerhans cells of the skin)
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325. Significant risk factor for Histiocytosis X?!?!?!
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a. 90% of patients are cigarette smokers.
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326. Variant diseases of Histiocytosis X?
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a. Eosinophilic granuloma (localised to bone or lung)
b. To systemic forms: 1. Letterer-Siwe disease 2. Hand-Schuller-Christian syndrome |
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327. 2 Common findings with Histiocytosis X?
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a. Dyspnea and nonproductive cough
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328. Other possible manifestations of Histiocytosis X?
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a. Spontaneous pneumothorax
b. Lytic bone lesions c. Diabetes insipidus |
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329. CXR and CT with Histiocytosis X?
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a. Honeycomb appearance
b. PT shows cystic lesions |
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330. Prognosis and course of Histiocytosis X?
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a. The prognosis and course are highly variable.
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331. Treatment of Histiocytosis X?
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a. Corticosteroids are sometimes effective
b. Lung transplant may be necessary |
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332. Pathophysiology Wegener's Granulomatosis?
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a. Characterized by necrotizing granulomatous vasculitis
b. Affects vessels of the lungs, kidneys, upper airways, and sometimes other organs |
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333. Presentation of Wegener's granulomatosis?
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a. Upper and lower respiratory infections
b. Glomerulonephritis c. Pulmonary nodules |
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334. Gold standard for diagnosis of Wegener's Granulomatosis?
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a. Tissue biopsy, but if the patient test positive for C-ANCA, the likelihood of having this condition is high
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335. Treatment of Wegener's Granulomatosis?
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a. Immunosuppressive agents in glucocorticoids
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336. Pathophysiology of Churg-Strauss syndrome?
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a. Granulomatous vasculitis seen in patients with asthma!
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337. Presentation of Churg-Strauss syndrome?
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a. Pulmonary infiltrates
b. Rash c. Eosinophilia d. Systemic vasculitis may result in skin, muscle, and nerve lesions |
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338. Diagnosis of Churg-Strauss syndrome?
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a. Significant blood eosinophilia is common
b. Associated with P-ANCA. |
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339. Treatment of Churg-Strauss syndrome?
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a. Systemic glucocorticoids
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340. C-ANCA is positive in what condition?
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a. Wegener's Granulomatosis
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341. P-ANCA is positive in what conditions?
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a. Churg-Strauss syndrome
b. May also be positively Goodpasture's |
