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47 Cards in this Set
- Front
- Back
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HERPES BASICS
- genome type - genome structure - capsid geometry - envelope |
- dsDNA
- Linear - ICOS - Yes |
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HERPES BASICS
- unique structure(s)? - located where? |
- Tegument
(proteinaceous material containing virus-encoded enzymes and TFs) - between ENV & Capsid (eTC |
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HERPES BASICS
- unique Replication Phases |
1.) Immediate-early
(gene transcription & regulatory prot.) 2.) Early (replication enzymes) 3.) Late (structural & assembly proteins) |
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HERPES BASICS
- Replication takes place where? |
- Nucleus
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HERPES BASICS
- unique derivation of one of its components |
- ENV is from NUCLEAR membrane
(all other DNA viruses get it from plasma membrane as it buds off) |
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HERPES BASICS
- Classes of herpesvirus family is differentiated by? |
- Biologic characteristics
(not morphological) |
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HERPES BASICS
- Alpha virus growth cycle? |
- Rapid, cytocidal growth cycle
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HERPES BASICS
- Beta virus growth cycle? |
- Slow, replicative cycle
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HERPES BASICS
- which herpes family results in Formation of Multinucleated Giant host cells? |
- Beta
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HERPES BASICS
- which herpes family results in Proliferation of Lymphoblastoid cells? |
- Gamma
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HERPES BASICS
- which herpes family has cytocidal features |
- Alpha
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HERPES BASICS
- Alpha viruses establish latency where? |
- Nerve ganglia
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HERPES BASICS
- Beta viruses establish latency where? |
- Macrophages
- Glandular tissue |
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HERPES BASICS
- Gamma viruses establish latency where? |
- Mucosal Epithelium
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HERPES BASICS
- List the alpha viruses |
- HSV I
- HSV II - VZV |
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HERPES BASICS
- list all the Beta viruses |
- CMV (HHV-5)
- Roseola (HHV-6) - HHV-7 |
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HERPES BASICS
- list all the Gamma viruses |
- EBV (HHV-4)
- KSHV (HHV-8) |
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ALPHA VIRUS
- HSV-1 has what symptoms |
(KEG TAP)
- Keratoconjunctivitis - Encephalitis of Temporal lobe - Gingivostomatitis - Tonsilitis - Aseptic Meningitis - Pharyngitis |
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ALPHA VIRUS
- describe the lesions for HSV |
- Painful, shallow vesicular lesions
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ALPHA VIRUS
- DX labs - results |
- Tzank smear
- Syncytium: Multinucleated Giant cells & - Cowdry type A: intraNuclear inclusions |
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ALPHA VIRUS
- Neonatal Herpes has the greatest risk of transmission when? |
- Primary infection at delivery
(get a C-section) |
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ALPHA VIRUS
- HSV DOC |
- Acyclovir
(alt. option: Valcyclovir or Famciclovir) |
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ALPHA VIRUS
- Neonatal Herpes DX lab test |
- PCR if herpes encephalitis
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ALPHA VIRUS
- Neonatal Herpes SX |
(PHASES)
- Periventricular calcifications - Hepatic Necrosis - Adrenal Necrosis - Skin vesicles - Encephalitis |
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ALPHA VIRUS
- VZV rash description |
crop of macules & papules at VARIOUS STAGES
occuring simultaneously. |
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ALPHA VIRUS
- Primary Varicella symptom? |
- Chicken pox
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ALPHA VIRUS
- what is Zoster etiology |
- Reactivation of Varicella
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ALPHA VIRUS
- Primary Zoster symptom |
- Shingles
(over single dermatome) |
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ALPHA VIRUS
- Zoster usually accompanies with? |
- Post herpetic neuralgia
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ALPHA VIRUS
- what is Reyes Syndrome |
Liver Failure
+ Encephalopathy in Kids recieving ASA during INFLUENZA or VZV infection |
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ALPHA VIRUS
- Primary complications of VZV? |
- Pneumonia
- Encephalitis |
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ALPHA VIRUS
- TX of VZV |
(same as HSV)
- Acyclovir (or Valciclovir/Famciclovir) |
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ALPHA VIRUS
- TX of VZV if patient is immunocompromised (includes neonates)? |
- add on VZIG within 72 horus
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ALPHA VIRUS
- TX of Postherpetic neuralgia - Postherpetic neuralgia associated with? |
- TCA or Gabapentin
- increased suicidality |
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ALPHA VIRUS
- where specifically on the nerve ganglia is the virus latent? |
- Dorsal root ganglia
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BETA VIRUS
- CMV would show what on slide? |
- Owl's eye inclusion
- Syncytia |
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BETA VIRUS
- CMV transmission |
(BUGS)
- Breast milk - Urine - Genital secretions - Saliva |
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BETA VIRUS
- Congenital CMV has what SX |
(PMS Blues)
- Periventricular calcifications - Microcephaly - Sensorineural deafness - Blueberry Muffin rash (non-blanching blue-red macules or papules) |
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BETA VIRUS
- Immunocompromised CMV symptoms |
(RICEE)
- Retinitis - Interstitial pneumonia - Colitis - Esophagitis - Encephalitis |
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BETA VIRUS
- which virus can cross placenta? |
- CMV
(TORCHS) |
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BETA VIRUS
- how does MONO with CMV differ from that of EBV? |
CMV - Negative for Heterophile Ab
EBV - Positive for Heterophile Ab |
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BETA VIRUS
- what is a heterophile antibody? |
- IgM antibodies that agglutinate horse and sheep RBC
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BETA VIRUS
- how is CMV retinitis sometimes described? |
- "Scarmbled Eggs & Ketchup"
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BETA VIRUS
- DX for CMV on slide |
- "Owl's Eye" intraNuclear inclusion body
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BETA VIRUS
- how is CMV treated? - why not use acyclovir |
- Gangciclovir
- b/c CMV does not have TKase |
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BETA VIRUS
- CMV retinitis in AIDS patients looks like what? |
- Retinal Opacification
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BETA VIRUS
- CMV can be Dx'd by serology with? |
- pp65 antigenemia
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