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20 Cards in this Set

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ANESTHETICS

- most anesthetics have what receptor activity
- enhance GABA-a receptor activity
ANESTHETICS

- anesthetic drugs must have what property?
- lipid soluble (to cross BBB)
or
- actively transported
ANESTHETICS

- drugs with LESS Solubility in BLOOD have what characters?
- Rapid Induction

- Rapid Recovery
ANESTHETICS

- drugs with MORE Solubility in LIPIDS have what character?
- greater Potency
ANESTHETICS

- Minimum Alveolar Concentration (MAC) is a measure of?

- a higher MAC indicates?
- measure of Potency

- lower potency
(potency = 1/MAC)
ANESTHETICS

- MAC values are analogous to what?
ED50

(% of inspired anesthetic at which 50% of patients are knocked the fuck out)
ANESTHETICS

- MAC is inversely proportional to?

- MAC values can be lowered (thus more potency) by concurrent administration of?
- Lipid solubility & Potency

- Opioid analgesics
(allows less anesthetics to be used)
ANESTHETICS

- what anesthetic has a MAC of greater than 100%?

- what does this mean in terms of ED50?

- what does this mean clinically?
- Nitric Oxide

(based on ED50, NO can not anesthetize 50% of population)

- NO can not be used as a sole single anesthetic
ANESTHETICS

- list the top 5 inhaled anesthetics from greatest lipid soluble to least

- thus, this list is same as?

- thus, this list is inverse of?
1.) Halothane
2.) Isoflurane
3.) Enflurane
4.) Ether
5.) NO

- Potency

- MAC
ANESTHETICS

- what is the Blood-Gas Partition Coefficient?
- anesthetic solubility in blood
ANESTHETICS

- more blood soluble anesthetics takes longer to achieve what in the brain?
- desired partial pressure in brain

(longer time to reach steady state)
ANESTHETICS

- Higher blood solubility implies what about onset of action & recovery time?
- Slow onset of action

- Slow Recovery time
ANESTHETICS

- what is the Most Blood Soluble inhaled anesthetic?

- what does this mean for its properties?
Halothane

- Slow onset of action
- Slow recovery
ANESTHETICS

- which drugs are nearly insoluble in the blood?
- Desflurane
- Sevoflurane

(both have low blood-gas solubility ratios, so rapid onset & rapid recovery)
ANESTHETICS

- rank the inhaled anesthetics from greatest to least for Blood-Gas Coefficient ratio
1.) Halothane
2.) Enflurane
3.) Isoflurane
4.) NO
ANESTHETICS

- Inhaled anesthetic that does NOT act on GABA-a receptors?
- NO
ANESTHETICS

- inhaled anesthetics that is associated with convulsions
- Enflurane
ANESTHETICS

- Halothane is associated with what SE?
- Hepatitis

- Malignant Hyperthermia
ANESTHETICS

- Halothane is associated with Malignant hyperthemia when used concomitantly with?

- Halothane is associated with Malignant Hyperthermia when deficiency with?
- Succinylcholine

- Ryanodine channel
ANESTHETICS

- inhaled anesthetics that is associated with nephrotoxicity?
methoxyflurane