S1 - Falcon - Pharm Neuro Anesthetic Drugs I

Front 1

ANESTHETICS

- most anesthetics have what receptor activity

Back 1

- enhance GABA-a receptor activity

Front 2

ANESTHETICS

- anesthetic drugs must have what property?

Back 2

- lipid soluble (to cross BBB)
or
- actively transported

Front 3

ANESTHETICS

- drugs with LESS Solubility in BLOOD have what characters?

Back 3

- Rapid Induction

- Rapid Recovery

Front 4

ANESTHETICS

- drugs with MORE Solubility in LIPIDS have what character?

Back 4

- greater Potency

Front 5

ANESTHETICS

- Minimum Alveolar Concentration (MAC) is a measure of?

- a higher MAC indicates?

Back 5

- measure of Potency

- lower potency
(potency = 1/MAC)

Front 6

ANESTHETICS

- MAC values are analogous to what?

Back 6

ED50

(% of inspired anesthetic at which 50% of patients are knocked the fuck out)

Front 7

ANESTHETICS

- MAC is inversely proportional to?

- MAC values can be lowered (thus more potency) by concurrent administration of?

Back 7

- Lipid solubility & Potency

- Opioid analgesics
(allows less anesthetics to be used)

Front 8

ANESTHETICS

- what anesthetic has a MAC of greater than 100%?

- what does this mean in terms of ED50?

- what does this mean clinically?

Back 8

- Nitric Oxide

(based on ED50, NO can not anesthetize 50% of population)

- NO can not be used as a sole single anesthetic

Front 9

ANESTHETICS

- list the top 5 inhaled anesthetics from greatest lipid soluble to least

- thus, this list is same as?

- thus, this list is inverse of?

Back 9

1.) Halothane
2.) Isoflurane
3.) Enflurane
4.) Ether
5.) NO

- Potency

- MAC

Front 10

ANESTHETICS

- what is the Blood-Gas Partition Coefficient?

Back 10

- anesthetic solubility in blood

Front 11

ANESTHETICS

- more blood soluble anesthetics takes longer to achieve what in the brain?

Back 11

- desired partial pressure in brain

(longer time to reach steady state)

Front 12

ANESTHETICS

- Higher blood solubility implies what about onset of action & recovery time?

Back 12

- Slow onset of action

- Slow Recovery time

Front 13

ANESTHETICS

- what is the Most Blood Soluble inhaled anesthetic?

- what does this mean for its properties?

Back 13

Halothane

- Slow onset of action
- Slow recovery

Front 14

ANESTHETICS

- which drugs are nearly insoluble in the blood?

Back 14

- Desflurane
- Sevoflurane

(both have low blood-gas solubility ratios, so rapid onset & rapid recovery)

Front 15

ANESTHETICS

- rank the inhaled anesthetics from greatest to least for Blood-Gas Coefficient ratio

Back 15

1.) Halothane
2.) Enflurane
3.) Isoflurane
4.) NO

Front 16

ANESTHETICS

- Inhaled anesthetic that does NOT act on GABA-a receptors?

Back 16

- NO

Front 17

ANESTHETICS

- inhaled anesthetics that is associated with convulsions

Back 17

- Enflurane

Front 18

ANESTHETICS

- Halothane is associated with what SE?

Back 18

- Hepatitis

- Malignant Hyperthermia

Front 19

ANESTHETICS

- Halothane is associated with Malignant hyperthemia when used concomitantly with?

- Halothane is associated with Malignant Hyperthermia when deficiency with?

Back 19

- Succinylcholine

- Ryanodine channel

Front 20

ANESTHETICS

- inhaled anesthetics that is associated with nephrotoxicity?

Back 20

methoxyflurane