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9 Cards in this Set
- Front
- Back
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Endproduct of aerobic glycosis vs. anaerobic glycolysis
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Pyruvate vs. Lactic acid
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Mechanism by which glucose is transported into cells
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GLUT-1: RBCs, brain
GLUT-2: Liver GLUT-4: Muscle, adipose tissue (insulin dependent) |
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Differences in location, Km, Vmax, regulation of hexokinase vs. glucokinase
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Location: Hexo in periphery; Gluco in liver
Km: Hexo low; Gluco high Vmas: Hexo low Vmax; Gluco high - Regulation: Hexo: G6P; Gluco: F6P + Regulation: Gluco: insulin & glucose |
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Function,+ and - regulation of PFK
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Function: F6P -> F1,6BP
- Regulation: ATP, citrate + Regulation: AMP, F2,6BP |
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Function,+ and - regulation of pyruvate kinase
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Function: PEP -> pyruvate
- Regulation: Glucagon (-) + Regulation: F1,6BP, insulin |
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Effects of pyruvate kinase deficiency
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Varying degrees of hemolytic anemia
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Function,coenzymes, + and - regulation of pyruvate dehydrogenase
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Function: Form acetyl CoA from pyruvate
Coenzymes: TPP, lipoic acid, CoA, NAD+, FAD + Regulation: NAD+, CoA, pyruvate - Regulation: ATP, Acetyl CoA, NADH |
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Most common cause of congenital lactic acidosis AND mechanism of arsenic poisoning
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Pyruvate dehydrogenase deficiency --> Deprives brain of acetyl CoA
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Total number of NADHs/FADH2s/ATPs from TCA and subsequent electron trans chain ATPs
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3 NADHs (9 ATP), 1 FADH2 (2 ATP) + 1 ATP = 12 ATP / 1 acetyl CoA
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