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38 Cards in this Set
- Front
- Back
Take them before you DINE
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H2 blockers (Cimetidine, ranitidine, famotidine, nizatidine)
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Use for ulcer, gastritis, mild esophageal reflux
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H2 blockers (Cimetidine, ranitidine, famotidine, nizatidine)
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Potent P-450 inhibitor
ANTIANDRONERGIC effects: prolactin release, gynecomastia, impotence, low libido in males) |
Cimetidine
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PPI
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Omeprazole
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PPI
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Lansoprazole
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Peptic ulcers, gastritis, esophageal reflux, Zollinger-Ellison syndrome
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PPI (Omeprazole, Lansoprazole) MOA: irreversibly inhibit H/K-ATPase in stomach parietal cells
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traveler's diarrhea and ulcer healing
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Bismuth and Sucralfate
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Tipple therapy for H.pylori ulcers
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Metronidazole, Amoxicillin (or Tetracycline), Bismuth
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Prevention of NSAID-induced peptic ulcers, maintenance of patent ductus arteriosus and to induce labor
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Misoprostol (MOA: a PGE1 analog. Decreases acid production, increases production and secretion of gastric mucous barrier)
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for Peptic ulcer (MOA: blocks M1(histamine secretions down) and M3 receptors on parietal cells (H+ secretion down)
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Pirenzepine and Propantheline
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SE of Antacid
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hypoKalemia
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Antacid Aluminum hydroxide SE
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minimum mount of feces (constipation) :) proximal muscle weakness, osteodystrophy and seizures
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Antacid Magnesium hydroxide SE
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hyporeflexia and cardiac arrest
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Antacid Calcium carbonate SE
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rebound acid
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Crohn's dx and Ulcerative colitis. Rx that is activated by colonic bacteria
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Sulfasalazine (sulfa rx)
SE reversible oligospermia |
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Crohn's and RA. Rx that screws up a proinflammatory cytokine TNF
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Infliximab
SE respiratory infection |
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Controls vomiting (you can go on dancing without vomiting:)) 5HT3 antagonist. Central acting antiemetic
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ONDANSetron
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Diabetic and post surgical gastroparesis
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Metoclopramide
SE parkinsonian effects, depression Interacts with digoxin and diabetic Rx |
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A lipid lowering agent whose SE is gallstones
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Clofibrate
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Rx that SE acute pancreatitis
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Sulfa drugs
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treat hereditory hemochromatosis
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Deferoxamine and phlebotomy
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Treat Wilson's dx with
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Penicillamine
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Nitrosamine exposure (also H.pylori, high salt intake) associated with?
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carcinoma of the stomach
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Acetaminophen OD (halothane and rifampin also)->?
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Centrilobular necrosis immediately around hepatic vein. Diffuse hepatic necrosis also possible
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Acute hepatitis caused by which rx?
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INH (isoniazid), nitrofurantoi, phenytoin. Acetaminophen is not associated with acute hep
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Salicylates, ethanol, tetracycline may cause?
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Fatty change in liver
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Heroin and other opiates stimulate which receptors of brain and GI tract?
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mue (m) pleasure sensation, decreased bowel motility. I.e. do not give opiates to pnts with bowel obstruction!
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Procainamide and hydralazine
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Drug induced Lupus!
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Which rx can cause a drug induced SLE?
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Procainamide and hydralazine
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PCP (Phencyclidine)
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inhibits depolarization of neurons and interferes with cognitive and other functions of the nervous system. Management-supportive care
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Antidode to anticholinergics when pnt ODed and looks like blind as a bat, hot as Hades, etc
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Physostigmine (AChAse inhibitor) that way Cholinergic activity is regained...
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all our locals love Jimson Weed!
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besides anti-cholinergic, massive hallucinations
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Methanol (wood alcohol) toxicity
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Alcohol dehydrogenase makes formic acid-TOXIC like a mother. Putamen hemorrhage on CT. Necrosis. Give EtOH to overwhelm dehydrogenase. Toxic to optic n (CNII)
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Stimulants: cocaine, amphetamine, theophylline, caffeine, hallucinogens, early effect of TCA
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tremor, agitation, mydriasis, tachycardia
diaphoretic, manic, seizures, hyperthermia |
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manage cocaine OD
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benzo
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Anticholinergics
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atropine, TCAs, phenothiazines
belladonna, antihistamines |
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Cholinergics:
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PRIMARY: bethanocol, mushrooms
Cholinesterase inhibitors: nerve agents, carbamates, organophosphate insecticides |
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OD on aspirin (salicilates) s&s:
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altered mental status, tinnitus, seizures; noncardiogenic pulmonary edema;
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