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11 Cards in this Set

  • Front
  • Back
Picornaviridae
SS RNA - non segmented
positive polarity
few proteins in Capsid (4 for polio)
Icosahedral capsid - no envelope
Capsid is stable to acid and the environment
RHINO are not acid stable
Coxsakievirus Group A
initial infection of the respiratory system. May turn into a viremia.

vesicular pharyngitis - induces anorexia dysphagia (HSV1 are throughout the oral cavity - distinguishing factors)

Summer grippe - febrile illness
Aseptic meningitis - stiff neck and back
COLDS
HFM disease
hemorrhagic conjuctivitis
Coxsakievirus group B
begins with a respiratory ifection but can spread to a viremia
Causes:
Summer grippe
epidemic myalgia - pain in chest
aseptic meningitis
neonatial disease - myocardial or pericardial disease, cyanosis, tachycardia, dyspnea
COLDS
Diabetes
Macular-papular rash

diagnose by virus isolation from throat, feces, or CSF
ECHOviruses
Initial respiratory infection
Causes:
Summer meningitis
summer epidemics of febrile illness with rash in kids
Rhinoviruses
nasopharyngeal isolation - stomach acid kills virus

Causes URI
No Fever
short lived immunity because on IgA
spread by droplet infections
Vaccine impractical/impossible
Could cause a LRI, and can be confused with H1N1.
Coronoviridae
SS RNA
positive polarity
Large
helical nucleocapsid (different)
2 glycoproteins in envelope
Replicate in cytoplasm
mature by budding
Poliovirus replication (coronaviridae example)
cytoplasmic replication cycle
replicative intermediate formed
nucleocapsids bud at PM
vesicles acquire viral envelop within peplomers
no cytopathic effecct
Coronavirus
5 antigenic groups
SARS is in group 2
Cause:
infectious bronchitis - adults sometimes cant be distinguished from colds
Pharyngitis
Usually Afebrile
SARS - LRI, High fever, cough, SOB, worldwide distribution
spread by sneezing
family members and hospital staff most likely to get infected

PCR detection
Vaccine in development
preventing spread of SARS - use quarantine
Adenoviridae
composed of DNA and protein capsid (12 peptide)
no envelope
icosahedral
capsid: 240 hexons - contacts 6 surrounding capsomers
12 pentons - contact 5 neughboring capsomers
Dense Nucleocapsid -

ONCOGENIC
Adenovirus cell interactions
infection is lytic
multiply in host cell membrane
induce latent infections in tonsils and other lymphoid organs in kids
stable to pH changes
small percent of respiratory disease

replication: makes early (enzymes) proteins and late (structural) proteins
Adenovirus
Up to half of URI's
preference for conjunctiva, respiratory epithelium, and lymph nodes
Affects children and elderly and military recruits
Does not affect college students

Types: 8, 7, 19 - shipyard conjuctivitis
Types: 7, 3 - fatal in infants and young children (pneumonia)
Types 2, 5 - pharyngitis

AB's persist for 10 years

live oral vaccine for types 4, 7- have oncogenic potential