Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
11 Cards in this Set
- Front
- Back
Picornaviridae
|
SS RNA - non segmented
positive polarity few proteins in Capsid (4 for polio) Icosahedral capsid - no envelope Capsid is stable to acid and the environment RHINO are not acid stable |
|
Coxsakievirus Group A
|
initial infection of the respiratory system. May turn into a viremia.
vesicular pharyngitis - induces anorexia dysphagia (HSV1 are throughout the oral cavity - distinguishing factors) Summer grippe - febrile illness Aseptic meningitis - stiff neck and back COLDS HFM disease hemorrhagic conjuctivitis |
|
Coxsakievirus group B
|
begins with a respiratory ifection but can spread to a viremia
Causes: Summer grippe epidemic myalgia - pain in chest aseptic meningitis neonatial disease - myocardial or pericardial disease, cyanosis, tachycardia, dyspnea COLDS Diabetes Macular-papular rash diagnose by virus isolation from throat, feces, or CSF |
|
ECHOviruses
|
Initial respiratory infection
Causes: Summer meningitis summer epidemics of febrile illness with rash in kids |
|
Rhinoviruses
|
nasopharyngeal isolation - stomach acid kills virus
Causes URI No Fever short lived immunity because on IgA spread by droplet infections Vaccine impractical/impossible Could cause a LRI, and can be confused with H1N1. |
|
Coronoviridae
|
SS RNA
positive polarity Large helical nucleocapsid (different) 2 glycoproteins in envelope Replicate in cytoplasm mature by budding |
|
Poliovirus replication (coronaviridae example)
|
cytoplasmic replication cycle
replicative intermediate formed nucleocapsids bud at PM vesicles acquire viral envelop within peplomers no cytopathic effecct |
|
Coronavirus
|
5 antigenic groups
SARS is in group 2 Cause: infectious bronchitis - adults sometimes cant be distinguished from colds Pharyngitis Usually Afebrile SARS - LRI, High fever, cough, SOB, worldwide distribution spread by sneezing family members and hospital staff most likely to get infected PCR detection Vaccine in development preventing spread of SARS - use quarantine |
|
Adenoviridae
|
composed of DNA and protein capsid (12 peptide)
no envelope icosahedral capsid: 240 hexons - contacts 6 surrounding capsomers 12 pentons - contact 5 neughboring capsomers Dense Nucleocapsid - ONCOGENIC |
|
Adenovirus cell interactions
|
infection is lytic
multiply in host cell membrane induce latent infections in tonsils and other lymphoid organs in kids stable to pH changes small percent of respiratory disease replication: makes early (enzymes) proteins and late (structural) proteins |
|
Adenovirus
|
Up to half of URI's
preference for conjunctiva, respiratory epithelium, and lymph nodes Affects children and elderly and military recruits Does not affect college students Types: 8, 7, 19 - shipyard conjuctivitis Types: 7, 3 - fatal in infants and young children (pneumonia) Types 2, 5 - pharyngitis AB's persist for 10 years live oral vaccine for types 4, 7- have oncogenic potential |