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7 Cards in this Set
- Front
- Back
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What is acne vulgaris?
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Chronic inflammation of the pilosebaceuous unit
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What is the most common disease seen by dermatologists?
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Acne vulgaris
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When does acne vulgaris begin?
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At an early age (9-11yo) and increases in severity in teenage years
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Describe the clinical lesions of acne vulgaris
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Inflammatory papules, pustules, nodules, cysts
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Describe the noninflamed comedones
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1. Plugging of the outlet of a hair follicle by keratin debris
2. Open comedone is called a "blackhead" 3. Closed comedone is called a "whitehead" |
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Describe the inflammatory type of acne vulgaris
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1. Abnormal keratinization of the follicular epithelium
2. Increased sebum production (androgen-dependent) 3. Bacterial lipase (Propionibacterium acnes) produces irritating fatty acids -Produces the inflammatory reaction |
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Describe the treatment of Acne vulgaris
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1. Topical agents - eg, topical retinoid + benzoyl peroxide
2. Systemic antibiotics - eg, tetracyclin (first choice); erythromycin 3. Systemic retinoids - isotretinoin (decreases follicular keratinization, sebum production, bacterial count) 4. Hormonal therapy - oral contraceptives (women; reduce free testosterone levels); antiandrogens (spironolactone) |
