Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
7 Cards in this Set
- Front
- Back
|
why can't DA be given directly for Parkinson's?
|
doesn't cross BBB
|
|
|
why does levo-dopa treatment fail to work as Parkinson's progresses?
|
the SNpc must have some DA secreting cells for levo-dopa treatment to work. as these all die, the levo-dopa doesn't have a CNS effect
|
|
|
a pt on levo-dopa may notice what SE
|
N/V, tachycardia
|
|
|
when giving L-dopa for Parkinson's, what drug must accompany it?
|
carbidopa - inhibit non-CNS aromatic-L-AA-decarboxylase
|
|
|
discuss MAOi and parkinsons Tx:
|
MAO inhibitors should be good for Parkinsons. however, systemic MAO inhibition, plus l-dopa, can lead to a dangerous HTN due to excess sympa agonism.
-thus a CNS-specific MAO-B is blocked by selegiline |
|
|
name two DA-R agonists
|
bromocriptine, pramipexole
|
|
|
what Parkinsons drug can be used in treating antipsychotic-drug-induced parkinsonism?
|
Benztropine, as it affects ACh pathways, not DA.
-it's a muscarinic-R antagonist |
