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26 Cards in this Set
- Front
- Back
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functional tolerance
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target tissue less sensitive to the drug
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withdrawal syndrome severity depends on
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extent and nature of underlying abnormality in CNS
rate of termination of drug action |
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nicotine poisoning
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CNS stimulation and convulsive activity followed by coma
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nicotine tolerance
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some functional tolerance develops
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nicotine dependence
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associated with EXTREME psychological dependence
hard to distinguish physical from psychological |
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treatment of nicotine dependence
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patch
buproprion varenicline |
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LSD MOA
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agonist at some 5HT receptors and antagonist at others
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LSD actions
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hallucinations
perceptual distortions mood changes, elation "bad trip" with large doses physio changes usually not pronounced |
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LSD tolerance
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not commonly seen
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physical dependence of LSD
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no abstinence syndrome has been seen
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treat "bad trip" with
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reassurance or a benzodiazepine
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PCP MOA
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binds to a site on the NMDA type glutamate receptor and blocks the cation channel
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PCP effects
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hallucinations
wild mood swings panic catatonia |
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Treatment of PCP toxicity
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acidification of the urine
diazepam to reduce agitation and prevent convulsions |
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PCP tolerance
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some but not well studied
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PCP dependence
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mild withdrawal symptoms
rats will self-administer PCP |
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marijuana MOA
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binds to G-protein coupled receptors that generally mediate inhibition of neuronal function
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THC metabolites can appear in urine for
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up to a week
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THC therapeutic uses
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excess intraocular pressure
toxin induced nausea and vomiting |
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THC tolerance
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tolerance to actions develops but decays rapidly
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Phsyio changes seen with THC
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increased heart rate and reddening of conjunctiva
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Physical dependence to THC
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little develops in the clinical setting
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MDMA
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ecstasy
associated with damage to 5HT neurons |
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only drugs of abuse that fail to act as positive reinforcers
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LSD and the other hallucinogens
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ascending dopamine pw originating in ventral tegmental area
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"reward pathway"
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determine psychic effect of a drug, how rewarding this is, and use this info to predict likelihood of abuse
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abuse liability
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