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24 Cards in this Set
- Front
- Back
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Older TCA's
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imipramine
amitryptylene nortriptylene |
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Atypical antidepressants
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buproprion
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SSRIs
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fluoxetine and sertraline
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fluoxetine inhibits metabolism of
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dextromethorphan (a selective antitussive)
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TCAs prevent reuptake of
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NE
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TCA SEs
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sedation
anti-muscarinic cardiac conduction problems aggrevation of psychoses and hypomania seizure risk weight gain sexual side effects |
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high risk of seizure
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buproprion
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high risk of sedation, antimuscarinic, and cardiac conduction problems
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amitriptylene
nortriptylene imipramine |
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less risk of weight gain
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buproprion
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high risk of sexual dysfunction
serotonin syndrome withdrawal syndrome |
SSRIs
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Amine reuptake inhibitor drug interactions
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MAOIs- hypertension
increase direct acting sympathomimetics decrease indirect acting sympathomimetics additive sedation and anti-muscarinic effects with many drugs |
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MAOIs and SSRIs
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serotonin syndrome
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MAOIs
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phenelzine, tranylcypromine, and selegiline
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Hypertensive crisis
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MAOIs and
1. foods with tyramine 2. sympathomimetics 3. levodopa |
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MAOIs and Buspirone
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HTN
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MAOIs and meperidine
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excitation
delirium convulsions hyperpyrexia rigidity |
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Tolerance
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most notable to autonomic actions; no clear tolerance to antidepressant effect
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Physical dependence
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mild withdrawal symptom can occur
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long-term treatment to reduce or prevent manic episodes
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lithium carbonate
valproic acid |
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Li
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narrow therapeutic range
elimination depends on Na+ levels decreased sodium levels lead to Li accumulation |
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Li SEs
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GI
fatigue fine hand tremor Diabetes Insipidus edema weight gain renal toxicity hypothyroidism teratogenesis toxicity in newborn increased PMNs |
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Therapeutic range of lithium
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Very Narrow!
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serotonin syndrome
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altered mental status, sweating, fever, tremor, and myoclonus
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no cardiotoxic or antimuscarinic actions
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SSRIs- fluoxetine and sertraline
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