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24 Cards in this Set

  • Front
  • Back
Older TCA's
imipramine
amitryptylene
nortriptylene
Atypical antidepressants
buproprion
SSRIs
fluoxetine and sertraline
fluoxetine inhibits metabolism of
dextromethorphan (a selective antitussive)
TCAs prevent reuptake of
NE
TCA SEs
sedation
anti-muscarinic
cardiac conduction problems
aggrevation of psychoses and hypomania
seizure risk
weight gain
sexual side effects
high risk of seizure
buproprion
high risk of sedation, antimuscarinic, and cardiac conduction problems
amitriptylene
nortriptylene
imipramine
less risk of weight gain
buproprion
high risk of sexual dysfunction
serotonin syndrome
withdrawal syndrome
SSRIs
Amine reuptake inhibitor drug interactions
MAOIs- hypertension
increase direct acting sympathomimetics
decrease indirect acting sympathomimetics
additive sedation and anti-muscarinic effects with many drugs
MAOIs and SSRIs
serotonin syndrome
MAOIs
phenelzine, tranylcypromine, and selegiline
Hypertensive crisis
MAOIs and
1. foods with tyramine
2. sympathomimetics
3. levodopa
MAOIs and Buspirone
HTN
MAOIs and meperidine
excitation
delirium
convulsions
hyperpyrexia
rigidity
Tolerance
most notable to autonomic actions; no clear tolerance to antidepressant effect
Physical dependence
mild withdrawal symptom can occur
long-term treatment to reduce or prevent manic episodes
lithium carbonate
valproic acid
Li
narrow therapeutic range
elimination depends on Na+ levels
decreased sodium levels lead to Li accumulation
Li SEs
GI
fatigue
fine hand tremor
Diabetes Insipidus
edema
weight gain
renal toxicity
hypothyroidism
teratogenesis
toxicity in newborn
increased PMNs
Therapeutic range of lithium
Very Narrow!
serotonin syndrome
altered mental status, sweating, fever, tremor, and myoclonus
no cardiotoxic or antimuscarinic actions
SSRIs- fluoxetine and sertraline