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45 Cards in this Set

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product of c-met onocogene
HGF receptor
mitogenic for epithelial cells, fibroblasts, and hepatocyte
EGF
TGF-alpha
involved in vasculogenesis and angiogenesis
VEGF
the main receptor for angiogenesis /vasculogensis that is expressed by endothelial cells
VEFGR-2
receptor on lymphatic cells for lymphatic growth
VEGFR-3
causes migration and proliferation of monocytes, fibroblasts, and plasma smooth muscle cells
PDGF
growth factor that binds to extracellular heparan sulfate to form pools of inactive growth factor
FGF (VEGF too?
growth factor centrally involved in wound repair, angiogenesis, and tissue development
FGF
growth factor produced by macrophages and is an inflammatory cytokine
TFG-beta
growth factor that promotes fibrosis by being chemotactic and mitogenic for fibroblasts. also stimulates collagen deposition
TGF-beta
Ras binds to ___ which activates _____
Raf, MAPK (mitogen associated protein kinases)
the ___ pathway activates a series of kinases including Akt that promote cell survival
PI3
type __ collagen is in BM
IV
type __ collagen is fibrillar collagen that is strongest
I
type ___ collagen is in cartilage
II
which enzyme needs vitamin C?
LYSINE OXIDASE!!
___ mediate contact inhibition
cadherins
___ mediate calcium dependent interactions b/t cells
cadherins
how do cadherins link up to the cytoskeleton
cadherin, beta catenin, alpha catenin, actin
what forms provisional blood clots during wound healing before fibrin deposition?
plasma fibronectin
wgat forms fibrillar aggregates at sites of wound healing
tissue fibronectin
most abundant glycoprotein in the BM
laminin
secreted adhesion molecule. contribute to tissue remodeling after injury and is an angiogenesis inhibitor
SPARC
secreted adhesion molecule. a family of large multifuctional proteins, some of which inhibit angiogenesis
thrombospondins
secreted adhesion molecule which regulates calcification and influences leukocyte migration
osteopontin
large multimeric proteins involved in cell adhesion and morphogenesis
tenacin
which is bigger hyaluronan or proteoglycans?
hyaluronan
growth factor associated with collagen synthesis
TGF beta
what is granulation tissue
deposited in a wound around 24 hours after injury. proliferating fibroblasts and endothelial cells in a loose matrix
where do new blood vessels come from
proliferation of existing ECs and also recruitment of EC precursors from bone marrow
what is the process of Angiogensesis?
NO dilates preexisting vessels
VEGF increases permeability
Metalloproteases degrade the BM
Plasminogen activator disrupts cell-cell contact
ECs proliferate and migrate toward angiogenic stimulus
ECs stop proliferating and mature. they remodel into capillary tubes
Periendothelial cells (for capillaries pericytes and for arteries vascular smooth muscle) are recruited
interacts with Tie2 to recruit periendothelial cells and mediate vessel maturation
Ang1
interacts with Tie2 to increase response to VEGF and cause proliferation and migration rather than maturation
Ang2
how does TGF beta stabilize new blood vessels
by promoting RCM production
how do proteaess that remodel tissue during EC invasion stimulate angiogenesis
they release matrix bound FGF and VEGF
how does fibronectin promote fibroblast engrowth?
it gives fibroblasts a matrix to bind to
which growth factors influence fibroblast migration and proliferation?
PDGF,
EGF,
FGF,
TGF-beta

also IL-1 and TNF
MMP production is inhibited by ___
TGF-beta
____ are membrane bound MMPs that release the extracellular domains of surface proteins like the precursor forms of TNF and TGF alpha
ADAMs
activated MMPs are inhibited by ___
TIMPs
in wound healing, what do epithelial cells do first: migrate, proliferate, or deposit BM?
they migrate first, deposit BM, and then finally proliferate
in wound healing, which cells come into the blood clot first?
pmn
does wound contraction occur in primary intention
no, just in second intention
tensile strength of a healed wound plateaus at ____ % at ___ months
70-80

3
why does wound strength continue to increase
collage switch to type I
larger diameter fibers
crosslinking of collage