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46 Cards in this Set
- Front
- Back
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What are the 6 ricketsial diseases
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1. RMSF
2. Human Granulocytic Ehrlichioisis (HGE) 3. Human Monocytic Ehrlichioisis (HME) 4. Q Fever 5. Endemic typhis 6. Epidemic typhis |
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What 2 things does the ricketssia secrete into the dermis?
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cement and immunity suppressors
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Rickettsia rickettsia: aerobic or anaerobic
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aerobic, utilize host glutamate TCA and ETC
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R. rickettsia: gram negative or positive
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negative
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R. rickettsia: intracellular or extracellular
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intracellular
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Some Nasty Bugs May Live FacultativeLY
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Salmonella
Niesseria Brucella Mycobacteria Listeria Francisella Legionella Yersina |
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R. rickettsia: What part of the body do these infect?
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endothelial cells lining capillaries, venules, etc.
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R. rickettsia: Where doe late stage infections harm?
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brain, heart and other vital organs + gangrene to extremeties caused by clots
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R. rickettsia: What do these bugs look like?
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pleomorphic coccobacilli, trilaminar membrane
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R. rickettsia: How do these guys move?
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- no flagella
- move by actin polymerization |
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R. ricketssia: how do they enter the host cell?
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induced endocytosis
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R. rickettsia: What is the primary disease thes e bugs cause?
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RMSF
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R. rickettsia: Major symptoms of RMSF
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1. petechial rash, begin on hands and feet, spreads to trunk
2. high fever 3. headache 4. myalgia 5. nausea, vomiting, Ab pain 6 conjunctivitis, edema |
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R. rickettsia: What are the neuro complications?
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stupor, delirium, coma
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R. rickettsia: What are the pulmonary complications?
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interstitial pneumonia, pulmonary edema
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R. rickettsia: What are the vascular complications?
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edema, hemorrhage, DIC
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R. rickettsia: What age has the highest incidence?
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Children
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R. rickettsia: What age has the highest death?
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Elderly
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R. rickettsia: What season is the most prevalent?
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summer
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R. rickettsia: What tick in the east?
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American dog tick
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R. rickettsia: What tick in the west?
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Rocky Mountain wood tick
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R. rickettsia: What is the Weil Felix test?
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Positive for typhus and RMSF, negative for Q fever
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R. rickettsia: 3 Tx options
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1. tet
2. doxy 3. chloramphenicol |
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R. rickettsia: reservoirs
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1. white footed mouse
2. ground squirrel 3. rabbit = amplifier |
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Coxiella burnetii: What is the major disease associate with this bug
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Q Fever
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C. burnetii: how is it transmitted?
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aerosol from animal placenta, amniotic fluid, dried urine + tick bites
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C. burnetii: reservoir
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cattle, sheep, goats
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C. burnetii: Clinical symptoms
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1. Sudden
2. high fever 3. pneumonia 4. acute: low mortality 5. chronic: endocarditis |
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C. burnetii: Dx method of choice
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IFA
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C. burnetii: Tx for acute and chronic?
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acute = doxy
chronic = doxy and chloroquine |
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C. burnetii: Where is the vaccine available?
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Australia
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C. burnetii: What do you do if you discover this bug?
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notify health dept.; potential bioweapon
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Human Erlichiosis: What are the common clinical symptoms
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fever, malaise, headache, myalgia, anorexia, chills, nausea, rash, cough, diarrhea, ab pain
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Human Erlichiosis: Severe symptoms
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DIC, pancytopenia, encephalitis, meningitis, pulmonary infarcts, GI bleed respiratory failure, renal failure, fatality
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Human Erlichiosis: Tx
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doxy
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Human Erlichiosis: Where do these grow?
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cytoplasm of the leukocyte
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Human Erlichiosis: How do these invade?
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morula break out of leukocyte and invade other cells
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Human Erlichiosis: Dx:
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blood smear, serology, PCR, IFA
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HGE: vector
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Ixodes scapularis
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HME: vector
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Amblyomma americanum
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HGE: reservoir
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small mammals
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HME: reservoir
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deer
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HGE and HME affect which sex more?
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males
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Rickettsia prowazekii: What disease does this cause?
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epidemic typhus
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R. prowazekii: reservoir
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flying squirrel
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R. prowazekii: Tx
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tet
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