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27 Cards in this Set

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Forms of chlamydiae

Elementary body (small, dense) is “Enfectious” and Enters cell via Endocytosis; transforms into reticulate body.
Reticulate body Replicates in cell by fission; Reorganizes into elementary bodies.

What diseases do Chlamydia trachomatis cause?

Reactive arthritis (Reiter syndrome), follicular conjunctivitis, nongonococcal urethritis, and PID.

What do Chlamydophila pneumoniae and C. psittaci cause?

Atypical pneumonia

Treatment of Chlamydiae infection?

Azithromycin (favored because one-time treatment) or doxycycline.

What lab tests are used to detect Chlamydiae?

Giemsa or fluorescent antibody–stained smear - cytoplasmic inclusions.

Mycoplasmal pneumonia symptoms

Insidious onset, headache, nonproductive cough, patchy or diffuse interstitial infiltration. X-ray looks worse than patient.

M. pneumoniae morphological features

Pleomorphic, no cell wall, not seen on Gram stain.

On what medium M.pneumoniae grows?

Eaton agar

Symptoms of Rocky Mountain spotted fever

Classic triad: headache, fever, rash (vasculitis), that typically starts at wrists and ankles and
then spreads to trunk, palms, and soles.

Treatment of Rocky Mountain spotted fever

Doxycycline

Where Rocky Mountain spotted fever is more common?

South Atlantic states, especially North Carolina.

Symptoms of typhus

Fever, headache and rash that starts centrally and spreads out, sparing palms and soles.

How to treat typhus?

Doxycycline

How to diagnose ehrlichiosis?

Monocytes with morulae (berry-like inclusions) in cytoplasm.

How to diagnose anaplasmosis?

Granulocytes with morulae in cytoplasm.

How Q fever is transmitted?

Spores inhaled as aerosols from cattle/sheep amniotic fluid.

Symptoms of Q fever

Pneumonia, endocarditis, no rash.

How C. pneumoniae and C. psittaci are transmitted?

By aerosol

Why b-lactams are not effective against Chlamydiae?

The chlamydial cell wall lacks classic
peptidoglycan (due to reduced muramic acid).

What laboratory finding is characteristic for M. pneumoniae?

High titer of cold agglutinins (IgM), which can agglutinate or lyse RBCs.

How to treat pneumonia, caused by M.pneumoniae?

Macrolide, doxycycline, or fluoroquinolone

What people are more likely gonna get M. pneumoniae?

Military recruits and prisoners.

What diseases are caused by A, B and C serotypes of C. trachomatis?

Chronic infection, blindness due to
follicular conjunctivitis in Africa.

What diseases are caused by D-K serotypes of C. trachomatis?

Urethritis/PID, ectopic pregnancy, neonatal
pneumonia (staccato cough) with eosinophilia,
neonatal conjunctivitis.

What diseases are caused by L1,L2 and L3 serotypes of C. trachomatis?

Lymphogranuloma venereum

Symptoms of lymphogranuloma venereum

Small, painless ulcers on genitals, followed by swollen painful inguinal lymph nodes that ulcerate (buboes).

How to treat lymphogranuloma venereum?

Doxycycline