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52 Cards in this Set
- Front
- Back
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What are some diseases caused by rickettsia?
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Rocky Mountain Spotted Fever
Boutonneuse fever African tick bite fever |
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What are some diseases caused by Ehrlichia/Anaplasma?
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Human monocytic
Human granulocytic |
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What is a disease caused by coxiella?
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Q fever
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Microscopically, where does rickettsiae grow?
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Obligate intracellular parasite; nucleus
Can generate own ATP/prots OR import hosts |
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What cells does rickettsiae infect?
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Endothelial cells
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What is the mechanism of Rickettsiae damage?
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Free radical production --> Peroxidation of cell membrane --> Vascular leak --> Coagulation --> Hemorrhage
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Where is a unique place for Rocky Mountain Spotted Fever?
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Palms, soles of feet
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What are some further complications from RMSF?
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Encephalitis
CNS endothelial infection Think about this - the bugs are causing endothelial damage. One more place where there IS endothelium is inside the brain! CSF pleocytosis |
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What is the "triad" of symptoms associated with RMSF?
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Fever
Rash Tick bite |
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Where is the locale of RMSF?
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Smokies up through montana.
It should be called the Smokey Mountain Spotted Fever! |
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What is the reservoir of RMSF?
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Small mammals, ticks
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What is the local for Butonneuse fever?
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Souther Europe, Northern Africa
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What is the key test for the diagnosis of RMSF?
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Immunohistopathology
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What should you use to treat RMSF?
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Doxycycline (first choice)
Fluoroquinoolones |
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What is ineffective for treating RMSF?
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Beta-lactams
Aminoglycosides |
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What should you not use to treat RMSF?
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Sulfonamides
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What is the bug that causes epidemic typhus?
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Rickettesa prowazekii
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What is the disease that Rickettesa prowazekii causes?
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Epidemic typhus
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What is the reservoir for R. prowazekii?
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Humans, FLYING SQUIRrELS!!!
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Other than this endemic disease associated with disasters, war, famine, and refugee situations, R. prowazekii causes this disease:
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Brill-Zinsser Disease.
Latent typhus - think Typhoid Mary! |
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What is the bacteria that causes endemic murine typhus
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Ricketessa typhi
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What disease does Ricketessa typhi cause?
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Endemic (Murine) typhis
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What is the vector for R. tyhpi?
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Fleas (feces)
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What is the reservoir for endemic typhus?
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Rodents
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What is the bug that causes Scrub typhus?
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Orientia tsutsugamushi
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What is the disease that Orientia tsutsugamushi?
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Scrub typhus
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Where is the locale for Scrub Typhus/Orientia tsutsugamushi?
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East asia: Think VIETNAM VETS!
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What is the vector for Orientia tsutsugumushi?
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CHIGGERS!!! with transovarian transfer
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What are the clinical features of Human monocytic erhlichiosis?
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Low white count
NO RASH! High platelets Tick bites |
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What is the treatment for Human monocytic erhlichiosis?
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Doxycycline
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What is the bacteria that causes Human monocytic erhlichiosis?
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Erhlichia chaffensis
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What is the disease that Erhlichia chaffensis causes?
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Human monocytic erhlichiosis
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What is the bacteria that causes Human granulocytic erhlichiosis?
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Anaplamsa phagocytophilum
Erhlichia ewingii |
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What is the vector for the erhlichiosis diseases?
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Ticks
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What is the locale for Human monocytic erhlichiosis?
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Mississippi valey, South
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What is the locale for Human granulocytic erhlichiosis?
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Northeast
North Central US |
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What is the distinctive histologic feature of Human monocytic erhlichiosis?
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Morula within Monocytes
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When is the time that ehrlichiosis and anaplasmosis are most common?
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Summer
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What is the method of virulence for ehrlichiosis and anaplasmosis?
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Type IV secretion system that interrupts P-L fusion
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What is the distinguishing feature of erhlichiosis?
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Leukopenia
NO RASH |
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What is the distinghishing feature of RMSF?
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Petechial rashes all over body, including the hands.
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What is the host cell for erlichia and anaplasm?
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Leukocytes (monocytes, PMNs)
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What is the host cell for Coxiella?
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Macrophages
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What is the cellular location of ehrlichia and anaplasma?
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Intracytoplasmic vacuole
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What is the cellular location of Rickettsia?
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Cytosol
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What is the morphology of Coxiella burnetii?
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Small coccobacillua
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What is the mechanism of entry of Coxiella burnetii?
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Inhalation; proliferates in the lung
Only need one to infect. |
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Where inside this cell does coxy live?
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macrophages
Phagolysosome; obligate intracellular |
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What is the clinical picture of Q fever?
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Self-limited flu-like illnes
Atypical pneumonia |
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Other than the most typical presentation, what are some other conditions caused by Q fever?
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Culture negative endocarditis
Hepatitis |
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What is the reservoir for Coxiella?
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Farm animals
House cats |
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What is the way that Coxiella is transmitted
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UNVEIL THE BIRTHING GOAT!!!
Partuition |
