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12 Cards in this Set
- Front
- Back
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What is SLE?
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• a multi-system autoimmune disorder of unknown cause
• characterized by periods of active disease and remission • manifestations ranging from mild dermatologic and joint symptoms to life-threatening internal organ failure and cytopenias |
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What are theoretical causes of some of the clinical manifestations of SLE?
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• trapping of antigen-antibody complexes in capillaries of visceral strucutres
• autoantibody-mediated destruction of host cells |
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True/False: SLE is more common in women
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The correct answer is: True
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What are manifestations of SLE that result in critical illness?
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• lupus nephritis
• lupus cerebritis • pulmonary hemorrhage • small vessel vasculitis |
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What are common cutaneous features of SLE?
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• alopecia
• discoid lesions • malar "butterfly" rash • nail fold infarcts • periungual erythema • photosensitivity • splinter hemorrhages • urticaria |
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Which autoantibodies are most specific for SLE?
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• Smith (Sm) antigen: 99% specific
• double-stranded DNA (dsDNA): 95% specific • Proliferating cell antigen (PCNA):95% specific • Ribonuclear protein (RNP): 87-94% specific |
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Which autoantibody is most sensitive to SLE?
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antinuclear antibodies (ANA)
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In SLE, which autoantibodies are associated with lupus nephritis?
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• anti-DNA
• anti-Smith |
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What are the criteria for diagnosing SLE?
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Pneumonic: DOPAMINE RASH
• D: Discoid rash • O: Oral aphthous ulcers • P: Photosensitivity • A: Arthritis • M: Malar rash • I: Immunologic criteria • N: Neurologic changes • E: ESR increased • R: Renal disease • A: ANA + • S: Serositis (pleurisy, pericarditis) • H: hematologic disease |
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What are the most common drugs that can cause drug-induced lupus erythematosus (DILE)?
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• Procadinamide*
• Hydralazine* • Chlorpromazine • INH • Methyldopa • Quinidine • Others (ex. anticonvulsants, beta-blockers, antimicrobials) * most studied drugs to cause SLE |
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What are 4 features of DILE that differentiate it from SLE?
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• sex ratio is nearly equal
• nephritis and CNS features are not usually present • hypocomplementemia & antibodies to native DNA are absent • clinical features & most lab abnormalities revert to normal when the offending drug is withdrawn |
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What are medical treatment options for SLE?
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• NSAIDS
• glucocorticoids • Hydroxychloroquine • Immunosuppressives (ex. Azathioprine, Mycophenolate mofetil, Cyclophosphamide) • IVIG • Methotrexate |
