Rheumatology Dejareview

Front 1

Describe the effect(s) of SLE on the following organ: Skin

Back 1

Malar rash, discoid rash, photosensitivity

Front 2

Describe the effect(s) of SLE on the following organ: Joints

Back 2

arthritis, arthralgias

Front 3

Describe the effect(s) of SLE on the following organ: CNS

Back 3

neuropsychiatric changes or seizures (secondary to cerebral vasculitis)

Front 4

Describe the effect(s) of SLE on the following organ: Heart

Back 4

Pericarditis, Libman-Sacks endocarditis (SLE-->LSE)

Front 5

Describe the effect(s) of SLE on the following organ: lungs

Back 5

Pleuritis, pulmonary fibrosis

Front 6

Describe the effect(s) of SLE on the following organ: GI

Back 6

Oral and nasopharyngeal ulcers

Front 7

Describe the effect(s) of SLE on the following organ: Kidneys

Back 7

wire-loop glomerular lesions and mesangial immune complex deposits leading to glomerulonephritis

Front 8

Describe the effect(s) of SLE on the following organ: Hematology

Back 8

hemolytic anemia, leukopenia, thrombocytopenia, Raynaud's phenomena

Front 9

What pathologic finding is common to all tissues affected by SLE?

Back 9

Acute necrotizing vasculitis of small arteries and arterioles caused by immune complex deposition

Front 10

Libman-Sacks endocarditis causes sterile vegetations to form on both sides of which cardiac valve?

Back 10

mitral valve

Front 11

Name five medications capable of inducing a lupus-like syndrome.

Back 11

Hydralazine, INH, phenytoin, procainamide, penicillamine

Front 12

Name the disease related to SLE that is characterized by immune complex deposition at the dermal-epidermal junction

Back 12

Discoid lupus erythematosus

Front 13

What disease is associated with ANA (antinuclear antibodies)?

Back 13

SLE (sensitive but not specific for SLE)

Front 14

What disease is associated with Anti-ACh (acetylcholine)?

Back 14

Myasthenia gravis

Front 15

What disease is associated with antibasement membrane antibody?

Back 15

Goodpasture's disease

Front 16

What disease is associated with anticentromere antibodies?

Back 16

CREST syndrome (Calcinosis, Raynaud's, Esophageal dysmotility, Sclerodactyly, Telangiectasias

Front 17

What disease is associated with Anti-dsDNA antibodies?

Back 17

SLE (highly specific for SLE)

Front 18

What disease is associated with antiepithelial cell antibodies?

Back 18

pemphigus vulgaris

Front 19

What disease is associated with antigliadin Ab?

Back 19

Celiac sprue

Front 20

What disease is associated with antihistone Ab?

Back 20

drug-induced lupus erythematosus

Front 21

What disease is associated with Anti-IgG Fc antibody?

Back 21

rheumatoid arthritis (this is rheumatoid factor)

Front 22

What disease is associated with AntiJo1 Ab?

Back 22

myositis

Front 23

What disease is associated with antimicrosomal Ab?

Back 23

hashimoto's thyroiditis

Front 24

What disease is associated with antimitochondrial Ab?

Back 24

primary biliary cirrhosis

Front 25

What disease is associated with Anti-nRNP (nuclear ribonucleoprotein)

Back 25

mixed connective tissue disease

Front 26

What disease is associated with antiplatelet Ab?

Back 26

ITP

Front 27

What disease is associated with Anti-Scl-70 (DNA topoisomerase 1)?

Back 27

Diffuse scleroderma

Front 28

What disease is associated with anti-smith Ab?

Back 28

SLE (highly specific for SLE)

Front 29

What disease is associated with Anti-SS-A (Ro) and anti-SS-B (La) Ab?

Back 29

Sjogren syndrome

Front 30

What disease is associated with antithyroglobulin Ab?

Back 30

Hashimoto's thyroiditis

Front 31

What disease is associated with anti-TSHr (TSH receptor) Ab?

Back 31

Grave's disease

Front 32

What disease is associated with C-ANCA?

Back 32

Wegener's granulomatosis

Front 33

What disease is associated with perinuclear pattern of antineutrophil cytoplasmic antibodies (P-ANCA)?

Back 33

Micropolyarteritis nodosa; Churg-Strauss

Front 34

Name the autoimmune disease of connective tissue associated with the following clinical and pathologic findings: keratoconjunctivitis sicca or xerophthalmia, xerostomia, and evidence of other connective tissue disease.

Back 34

Sjogren syndrome

Front 35

Name the autoimmune disease of connective tissue associated with the following clinical and pathologic findings: myositis and heliotrope rash.

Back 35

Dermatomyositis

Front 36

Name the autoimmune disease of connective tissue associated with the following clinical and pathologic findings: rapidly progressive diffuse fibrosis of skin and involved organs including the heart, GI tract, kidney, lung, muscle, and skin

Back 36

Diffuse scleroderma

Front 37

Name the autoimmune disease of connective tissue associated with the following clinical and pathologic findings: CREST syndrome

Back 37

localized scleroderma

Front 38

Name the autoimmune disease of connective tissue associated with the following clinical and pathologic findings: disease of connective tissue that lacks renal involvement.

Back 38

mixed connective tissue disease

Front 39

What is the most common cause of death due to scleroderma?

Back 39

renal crisis (occurs in 50% deaths from scleroderma; treat with ACE inhibitors)

Front 40

Name the group of disorders characterized by extracellular deposition of protein in a beta-pleated sheet conformation.

Back 40

Amyloidosis (birefringence with Congo Red stain)

Front 41

Name the effect of amyloidosis on the following organ: kidneys

Back 41

Glomerular, peritubular, and vascular hyalinization

Front 42

Name the effect of amyloidosis on the following organ: liver

Back 42

hepatomegaly (amyloid deposition in space of Disse)

Front 43

Name the effect of amyloidosis on the following organ: heart

Back 43

restrictive cardiomyopathy

Front 44

Name the effect of amyloidosis on the following organ: tongue

Back 44

hypertrophy due to amyloid deposition