Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/44

Click to flip

44 Cards in this Set

  • Front
  • Back
Describe the effect(s) of SLE on the following organ: Skin
Malar rash, discoid rash, photosensitivity
Describe the effect(s) of SLE on the following organ: Joints
arthritis, arthralgias
Describe the effect(s) of SLE on the following organ: CNS
neuropsychiatric changes or seizures (secondary to cerebral vasculitis)
Describe the effect(s) of SLE on the following organ: Heart
Pericarditis, Libman-Sacks endocarditis (SLE-->LSE)
Describe the effect(s) of SLE on the following organ: lungs
Pleuritis, pulmonary fibrosis
Describe the effect(s) of SLE on the following organ: GI
Oral and nasopharyngeal ulcers
Describe the effect(s) of SLE on the following organ: Kidneys
wire-loop glomerular lesions and mesangial immune complex deposits leading to glomerulonephritis
Describe the effect(s) of SLE on the following organ: Hematology
hemolytic anemia, leukopenia, thrombocytopenia, Raynaud's phenomena
What pathologic finding is common to all tissues affected by SLE?
Acute necrotizing vasculitis of small arteries and arterioles caused by immune complex deposition
Libman-Sacks endocarditis causes sterile vegetations to form on both sides of which cardiac valve?
mitral valve
Name five medications capable of inducing a lupus-like syndrome.
Hydralazine, INH, phenytoin, procainamide, penicillamine
Name the disease related to SLE that is characterized by immune complex deposition at the dermal-epidermal junction
Discoid lupus erythematosus
What disease is associated with ANA (antinuclear antibodies)?
SLE (sensitive but not specific for SLE)
What disease is associated with Anti-ACh (acetylcholine)?
Myasthenia gravis
What disease is associated with antibasement membrane antibody?
Goodpasture's disease
What disease is associated with anticentromere antibodies?
CREST syndrome (Calcinosis, Raynaud's, Esophageal dysmotility, Sclerodactyly, Telangiectasias
What disease is associated with Anti-dsDNA antibodies?
SLE (highly specific for SLE)
What disease is associated with antiepithelial cell antibodies?
pemphigus vulgaris
What disease is associated with antigliadin Ab?
Celiac sprue
What disease is associated with antihistone Ab?
drug-induced lupus erythematosus
What disease is associated with Anti-IgG Fc antibody?
rheumatoid arthritis (this is rheumatoid factor)
What disease is associated with AntiJo1 Ab?
myositis
What disease is associated with antimicrosomal Ab?
hashimoto's thyroiditis
What disease is associated with antimitochondrial Ab?
primary biliary cirrhosis
What disease is associated with Anti-nRNP (nuclear ribonucleoprotein)
mixed connective tissue disease
What disease is associated with antiplatelet Ab?
ITP
What disease is associated with Anti-Scl-70 (DNA topoisomerase 1)?
Diffuse scleroderma
What disease is associated with anti-smith Ab?
SLE (highly specific for SLE)
What disease is associated with Anti-SS-A (Ro) and anti-SS-B (La) Ab?
Sjogren syndrome
What disease is associated with antithyroglobulin Ab?
Hashimoto's thyroiditis
What disease is associated with anti-TSHr (TSH receptor) Ab?
Grave's disease
What disease is associated with C-ANCA?
Wegener's granulomatosis
What disease is associated with perinuclear pattern of antineutrophil cytoplasmic antibodies (P-ANCA)?
Micropolyarteritis nodosa; Churg-Strauss
Name the autoimmune disease of connective tissue associated with the following clinical and pathologic findings: keratoconjunctivitis sicca or xerophthalmia, xerostomia, and evidence of other connective tissue disease.
Sjogren syndrome
Name the autoimmune disease of connective tissue associated with the following clinical and pathologic findings: myositis and heliotrope rash.
Dermatomyositis
Name the autoimmune disease of connective tissue associated with the following clinical and pathologic findings: rapidly progressive diffuse fibrosis of skin and involved organs including the heart, GI tract, kidney, lung, muscle, and skin
Diffuse scleroderma
Name the autoimmune disease of connective tissue associated with the following clinical and pathologic findings: CREST syndrome
localized scleroderma
Name the autoimmune disease of connective tissue associated with the following clinical and pathologic findings: disease of connective tissue that lacks renal involvement.
mixed connective tissue disease
What is the most common cause of death due to scleroderma?
renal crisis (occurs in 50% deaths from scleroderma; treat with ACE inhibitors)
Name the group of disorders characterized by extracellular deposition of protein in a beta-pleated sheet conformation.
Amyloidosis (birefringence with Congo Red stain)
Name the effect of amyloidosis on the following organ: kidneys
Glomerular, peritubular, and vascular hyalinization
Name the effect of amyloidosis on the following organ: liver
hepatomegaly (amyloid deposition in space of Disse)
Name the effect of amyloidosis on the following organ: heart
restrictive cardiomyopathy
Name the effect of amyloidosis on the following organ: tongue
hypertrophy due to amyloid deposition