• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/25

Click to flip

25 Cards in this Set

  • Front
  • Back
Collagen Vascular Disease: synonyms
Systemic inflammatory rheumatic diseases
Systemic inflammatory diseases
Connective tissue diseases
Collagen Vascular Disease: types
SLE
Scleroderma
Polymyositis/dermatomyositis
Collagen Vascular Disease: common features
Multisystem involvement (skin, joints, muscle, lung, kidneys, blood)
Demographics (Women>men, young and middle aged)
Constitutional symptoms (weight loss, fever, fatigue, arthralgia, myalgia)
Lab findings (anemia, elevated ESR/CRP, organ specific markers, serologic markers)
Collagen Vascular Disease: common pathologies
Immune activation/abnormalities > Inflammation > Vasculopathy > Fibrosis
Collagen Vascular Disease: Immune activation/abnormatlities
ANA antibodies
Other specific autoantibodies
Low serum complements
Antibody complexes
Collagen Vascular Disease: Vasculopathy
Fibrotic intimal hyperplasia
Adventitial fibrosis
Arterial lumen severely compromised
Collagen Vascular Disease: Fibrosis
Scar tissue in organs due to untreated inflammations
SLE: Pathogenic characterisitics (in order of importance)
Immune activation/abnormalities, inflammation
Vasculopathy
Fibrosis
SLE: pathogenesis
1. Excessive auto-antibody formation (ANA,anti-dsDNA etc.)
2. Cytotoxic antibodies and immune complexes cause inflammation and destroy tissue
3. Immune complexes cause: low serum C3/C4, glomerlulonephritis
4. Cytotoxic antibodies cause hemolytic anemia
SLE: Classification criteria for SLE (need 4/11 for diagnosis)
malar rash, discoid rash, photosensitivity, oral ulcers, arthrtitis, serositis, renal diease, seizures/psychosis, hematologic abnormalities, ANA, Immunologic
SLE: Signs and symptoms
Rash (butterfly, scalp), alopecia, oral ulcers, raynaud's
Kidney: proteinuria, renal insufficiency, glomerulonephritis
Lungs: Pleuritis, pleural effusion, pneumonitis
Cardiac: pericarditis, myocarditis, endocarditis, premature atherosclerosis
Hematologic: cytopenias in any cell line
Scleroderma: Pathogenic characteristics (in order of importance)
Fibrosis=Vasculopathy >Immune activation/abnormalitiy >Inflammation
Scleroderma: classification
Localized: skin only
Generalized: Limited (CREST syndrome), Diffuse (progressive systemic sclerosis)
Scleroderma: CREST syndrome manifestations
Calcinosis (fingers)
Raynaud's
Esophageal dysmotility
Sclerodactyly
Telangiectasia
Scleroderma: Progressive Systemic Sclerosis Manifestations
Skin: widespread invovement
Lung: interstitial pulmonary fibrosis
Colon: wide-mouthed diverticula
Dermatomyositis/polymyositis: Pathogenic characterisitcs
Inflammation > Immune activation/abnormalities > vasculopathy > fibrosis
Dermatomyositis/polymyositis: Chief complaint
Muscle weakness
Polymyositis: pathogenesis
Interstitial mononuclear cell infiltrate in muscle fibres
Myocyte necrosis
Dermatomyositis: Clinical features
Myositis: similar to polymyositis
Skin rash: Heliotropic, shawl sign, Gottron's papules
Vasculopathy: nailfold capillaries, Raynaud's
Myositis: diagnosis
Hx and Px: muscle weakness
Blood: elevated CK, anti-Jo1
Confirm by: EMG, MRI, Muscle biopsy (gold standard)
Collagen Vascular Disease: Treatment of inflammation
Corticosteroids: oral, IV
Azathioprine
Methotrexate
Mycophenolate Mofetil
Cyclophosphamide
Hydroxychloroquine (SLE)
Collagen Vascular Disease: Treatment of vasculopathy
Vasodilators: CCB's, etc.
Endothelial active agents
Collagen Vascular Disease: Treatment of fibrosis
none
Collagen Vascular Disease: Treatment of immune abnormalities
No need, monitor and treat organs that are affected
Corticosteroids: adverse effects
Acute: infection, steroid psychosis, steroid myopathy
Chronic: Truncal obesity, moon face, acne, hirsutism, hypertension, hyperglycemia, skin atrophy, cataracts, fluid retention, osteoporosis, avascular necrosis