Rheumatoid Arthritis - Session1

Front 1

Rheumatoid Arthritis
Chronic,systemic inflammatory type
of polyarticular arthritis that is of
auto immune in nature with articular
and extra-articular manifestations leading to crippling deformities and
disability and eventual death

Back 1

Etiology of RA
Auto immune destruction of
articular cartilage and progressive synovitis,and inflammation of
tendons,ligaments and capsules and periarticular structures

Front 2

Inflammation is marked by rise in
serum markers
ESR
anti- Citrulline cyclic Peptides
CRP
amylase

Back 2

Proinflammatory cytokines trigger the
synovial proliferation leading to hyperemia
pannus formation
Rheumatoid Nodules
vasculitis

Front 3

Auto antibodies to IgG, IgM
believed to be the trigger to cascade
of inflammatory events

Back 3

Incidence of RA
21 million americans
1% of the population
Females > males

Front 4

Clinical Manifestations-
morning stiffness
arthritis > 3 joints
symmetric involvement
serum Rheumatoid factor + ve
Typical evidence of radiological changes

Back 4

clinical manifestations-
Rheumatoid nodules (subcutanoeus)
seen in elbows,knees,feet,hand
Extra-articular manifestations
blood vessels(vasculitis)
lungs(pleural effusions)
eyes(scleritis)

Front 5

joint warmth and tenderness
fusiform swelling of soft tissue
juxtra-articular osteoporosis
marginal erosion
bony cysts
ligament laxity
joint subluxations (C1-C2)

Back 5

Bursitis
achilles pain
various deformities -wrist and hand
deformities of hip.knee and ankle and foot