Rheumatoid Arthritis Dmards & Biologics

Front 1

What does DMARD stand for?

Back 1

Disease-Modifying Antirheumatic Drugs

Front 2

What does BRMs stand for?

Back 2

Biologic Response Modifiers

Front 3

What class is methotrexate in?

Back 3

DMARDs

Front 4

This drug is in an inhibitor of dihydrofolate reductase.

Back 4

methotrexate

Front 5

MTX inhibits formation of DNA and RNA in rapidly proliferating tissues of what?

Back 5

lymphocytes, bone marrow, GI muscosa

Front 6

The 2 hypothesis of MTX?

Back 6

Polyamine Hypothesis

Adenosine Hypothesis

Front 7

Potent extracellular anti-inflammatory mediator?

Back 7

extracellular adenosine

Front 8

Which drug is the stand of DMARDs?

Back 8

methotrexate

Front 9

What class is hydroxychloroquine in?

Back 9

DMARDs

Front 10

Developed as an antimalarial drug?

Back 10

hydroxychloroquine

Front 11

What DMARD causes ocular toxicity?

Back 11

hydroxychloroquine

Front 12

What class is sulfasalazine in?

Back 12

DMARDs

Front 13

What class is leflunomide in?

Back 13

DMARDs

Front 14

Which drug inhibits the enzyme dihyroortate dehydrogenase?

Back 14

leflunomide

Front 15

What class are gold salts in?

Back 15

DMARDs

Front 16

What class is azathioprine in?

Back 16

DMARDs

Front 17

What class is D-Penicillamine in?

Back 17

DMARDs

Front 18

What class is minocycline in?

Back 18

DMARDs

Front 19

What drug is a purine antimetabolite?

Back 19

azathioprine

Front 20

What drug is a metal chelating agent?

Back 20

D-Penicillamine

Front 21

Infliximab

Back 21

Remicade

Front 22

Adalimumab

Back 22

Humira

Front 23

Golimumab

Back 23

Simponi

Front 24

Infliximab

Back 24

TNF-α antagonist

Front 25

Adalimumab

Back 25

TNF-α antagonist

Front 26

Golimumab

Back 26

TNF-α antagonist

Front 27

Certolizumab

Back 27

Cimzia

Front 28

Recombinant, humanized antibody Fab fragment with specificity for human TNF-α , conjugated to a ~40 kDa polyethylene glycol (PEG) to enhance plasma half-life?

Back 28

Certolizumab

Front 29

Etanercept

Back 29

Enbrel

Front 30

This drug binds up 2 TNF-α?

Back 30

Etanercept

Front 31

Anakinra

Back 31

Kineret

Front 32

Which drug is the Interleukin-1 receptor antagonist?

Back 32

Anakinra

Front 33

Tocilizumab

Back 33

Actemra

Front 34

What drug is the anti-interleukin-6 receptor antagonist?

Back 34

Tocilizumab

Front 35

Pro-inflammatory cytokines?

Back 35

TNF-α
IL-1
IL-6

Front 36

Abatacept

Back 36

Orencia

Front 37

Which drug is a costimulation blocker?

Back 37

Abatacept

Front 38

Rituximab

Back 38

Rituxan

Front 39

Which drug leads to B cell depletion?

Back 39

Rituximab

Front 40

Administration from of infliximab?

Back 40

IV

Front 41

Administration form of rituximab?

Back 41

IV

Front 42

Administration form of abatacept?

Back 42

IV

Front 43

Administration form of tocilizumab?

Back 43

IV

Front 44

Administration form of etanercept?

Back 44

SC

Front 45

Administration form of adalimumab?

Back 45

SC

Front 46

Administration form of anakinra?

Back 46

SC

Front 47

Administration form of certolizumab?

Back 47

SC

Front 48

Administration form of golimumab?

Back 48

SC

Front 49

Which drugs have half-life of 4 to 20 days?

Back 49

Etanercept, Infliximab, Tocilizumab, Adalumimab, Abatacept, Certolizumab

Front 50

Which drug has a half-life of 60 hours?

Back 50

Rituximab

Front 51

Which drug has a half-life of 4 to 6 hours?

Back 51

Anakinra