Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key


Play button


Play button




Click to flip

8 Cards in this Set

  • Front
  • Back
Rheumatoid factor
It is an antibody against the Fc portion of IgG = RF & IgG form immune complexes.
* which is itself an antibody, IgM or IgA type.
RF or RhF positive in:
is often determined in patients suspected in any form of arthritis
* High levels RF: generally > 20 IU/mL
* rheumatoid arthritis: present in 80%
* Sjögren's syndrome: present in 60%
false (+) RF or RhF
Blood test performed in patients with suspected rheumatoid arthritis (RA)
* Chronic hepatitis
* Any chronic viral infection
* Leukemia
* Dermatomyositis
* Infectious mononucleosis
* Scleroderma
* Systemic lupus erythematosus (SLE)
Sjögren's syndrome
* antibodies to Ro(SSA) or La(SSB) antigens, or both
* > 40 years old at the time of diagnosis & Woman >> Man
* an autoimmune disorder in which immune cells attack and destroy the exocrine glands that produce tears and saliva with Schirmer test(+)
* A lip biopsy can reveal lymphocytes clustered around salivary gland
Group of related INFLAMMATORY JOINT Ds associated with the MHC class I molecule HLA-B27
Seronegative spondylarthropathy
Spondylarthropathy & (-)rheumatoid factor (RhF)
Non-specific spondylarthropathy
Indicator of other rheumatological disease (in particular rheumatoid arthritis)
Subgroups (with increased HLA-B27 frequency)
* ankylosing spondylitis Caucasians (AS, 92%),
* ankylosing spondylitis African-Americans (AS, 50%),
* reactive arthritis (Reiter's syndrome) (RS, 60-80%),
* enteropathic arthritis associated with inflammatory bowel disease (IBD, 60%),
* Psoriatic arthritis (60%),
* isolated acute anterior uveitis (AAU, iritis or iridocyclitis, 50%), and
* undifferentiated SpA (USpA, 20-25%).