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8 Cards in this Set
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Rheumatoid factor
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It is an antibody against the Fc portion of IgG = RF & IgG form immune complexes.
* which is itself an antibody, IgM or IgA type. |
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RF or RhF positive in:
is often determined in patients suspected in any form of arthritis |
* High levels RF: generally > 20 IU/mL
* rheumatoid arthritis: present in 80% * Sjögren's syndrome: present in 60% |
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false (+) RF or RhF
Blood test performed in patients with suspected rheumatoid arthritis (RA) |
* Chronic hepatitis
* Any chronic viral infection * Leukemia * Dermatomyositis * Infectious mononucleosis * Scleroderma * Systemic lupus erythematosus (SLE) |
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Sjögren's syndrome
* antibodies to Ro(SSA) or La(SSB) antigens, or both * > 40 years old at the time of diagnosis & Woman >> Man |
* an autoimmune disorder in which immune cells attack and destroy the exocrine glands that produce tears and saliva with Schirmer test(+)
* A lip biopsy can reveal lymphocytes clustered around salivary gland |
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Spondyloarthropathies
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Group of related INFLAMMATORY JOINT Ds associated with the MHC class I molecule HLA-B27
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Seronegative spondylarthropathy
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Spondylarthropathy & (-)rheumatoid factor (RhF)
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Non-specific spondylarthropathy
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Indicator of other rheumatological disease (in particular rheumatoid arthritis)
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Subgroups (with increased HLA-B27 frequency)
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* ankylosing spondylitis Caucasians (AS, 92%),
* ankylosing spondylitis African-Americans (AS, 50%), * reactive arthritis (Reiter's syndrome) (RS, 60-80%), * enteropathic arthritis associated with inflammatory bowel disease (IBD, 60%), * Psoriatic arthritis (60%), * isolated acute anterior uveitis (AAU, iritis or iridocyclitis, 50%), and * undifferentiated SpA (USpA, 20-25%). |
