Rheum

Front 1

Felty's syndrome is . . .

Back 1

RA, splenomegaly, neutropenia

Front 2

Positive lab test most frequently associated with diffuse cutaneous systemic sclerosis and an increased risk for interstitial lung disease

Back 2

anti-Scl 70

Front 3

Polymyalgia rheumatica

Back 3

pain and morning stiffness in the axial joints and proximal muscles and an absence of restricted motion, generally without swelling, pain, and warmth of the proximal joints; elevated ESR and rarely occurs in patients <50 years of age

Front 4

Tx of choice for scleroderma renal crisis

Back 4

short acting ACE-i (captopril)

Front 5

Adult-onset Still's disease

Back 5

daily, high spikes of fever; arthritis; and a salmon-colored rash; often ferritin levels >3000

Front 6

which acne drug commonly (relatively) causes drug induced lupus?

Back 6

minocycline

Front 7

in adults, parvo B-19 infection is not "slapped cheeks" like it is in children but instead is . . .

Back 7

may mimic rheumatoid arthritis,self-limited, may not have an associated rash, resolves within 1 to 2 months, and usually responds to nonsteroidal anti-inflammatory drugs

Front 8

Polymyalgia rheumatica Dx?
Tx?

Back 8

pain or morning stiffness in the neck or torso, shoulders and upper arms, or hips and thighs in patients >50 years of age with an erythrocyte sedimentation rate >40

Front 9

Goal uric acid level in a pt treated w allopurinol for gout is?

Back 9

<6

Front 10

In any patient with dermatomyositis screen for ...

Back 10

underlying CA - DM is a very common paraneoplastic phenomenon

Front 11

what CA screening is recommended in asymptomatic pts on cyclophosphamide?

Back 11

bladder CA with urinalysis

Front 12

Colchicine can cause what type of neuromuscular side effect?

Back 12

acute vacuolar myopathy and axonal neu

Front 13

For SLE, what are the preferred meds for management during pregnancy?

Back 13

prednisone and hydroxychloroquine (first step is uptitration of prednisone)

Front 14

Wegener's granulomatosis

Back 14

necrotizing granulomatous inflammation of small- to medium-sized vessels with a predilection for the upper and lower respiratory tracts and kidneys.

Front 15

erythema nodosum (causes)

Back 15

sarcoid; Lymphomas; fungal or streptococcal infections; inflammatory bowel disease; and some medications, including estrogen

Front 16

Löfgren's syndrome

Back 16

a variant of sarcoidosis, is characterized by the concomitant presence of acute erythema nodosum, hilar adenopathy, arthritis or periarthritis, and fever

Front 17

Inclusion body myositis

Back 17

proximal and distal muscle involvement, asymmetrical muscle weakness and atrophy, falls, and mixed neuropathic and myopathic findings on electromyography; further Dx info from muscle biopsy

Front 18

Which thyroid med is most strongly associated with the development of antineutrophil cytoplasmic antibodies directed against myeloperoxidase and associated vasculitis

Back 18

propothyuracil

Front 19

Whipple's disease

Back 19

chronic infection with multiorgan manifestations, including uveitis, diplopia, asymmetrical inflammatory arthritis, and weight loss

Front 20

polymyalgia rheumatica (manifestations and Tx)

Back 20

patients >50 years of age, manifests as proximal pain, sometimes is accompanied by a sense of weakness of the upper and lower extremities, and usually is associated with an elevated erythrocyte sedimentation rate; treat w lower doses steroids vs giant cell arteritis

Front 21

the potentially most-harmful side effect of hydroxychloroquine is . . .

Back 21

retinal toxicity

Front 22

what rash is associated with rheumatic fever?

Back 22

erythema marginatum, is evanescent, nonpruritic, pink or faintly red, and macular (flat

Front 23

what rash is associated with adult onset Still's disease?

Back 23

evanescent salmon-colored rash

Front 24

Tx for Raynauds that is resistant to conservative (avoidance of triggers) therapy)?

Back 24

calcium channel blockers

Front 25

antisynthetase (anti–Jo-1 antibody) syndrome

Back 25

a polymyositis: proximal muscle weakness, elevated creatine kinase levels, abnormal electromyography findings, interstitial lung disease, and “mechanic's hands,”

Front 26

organisms that cause reactive arthritis

Back 26

Salmonella, Shigella, Clostridium difficile, or Chlamydia

Front 27

what CA is Sjogren's syndrome commonly associated with?

Back 27

increased risk for non-Hodgkin's lymphoma and other lymphoproliferative conditions

Front 28

polyarteritis nodosum (PAN)

Back 28

medium vessel vasculitis; fever, abd pain, livedo reticularis, mononeuritis multiplex, anemia, elevated ESR; associated with hep B in 10% of cases

Front 29

Extra-articular manifestations of ankylosing spondylitis

Back 29

aortitis with aortic insufficiency, upper-lobe pulmonary fibrocystic disease, amyloidosis, cardiac conduction disease, and recurrent uveitis

Front 30

Bechets disease

Back 30

recurrent aphthous oral ulcers and at least two or more of the following features: recurrent genital ulceration, eye or cutaneous lesions, or positive findings on pathergy testing

Front 31

characteristics of synovial fluid in septic arthitis

Back 31

highly inflammatory with a leukocyte count between 10,000/µL (10 × 109/L) and 50,000/µL (50 × 109/L) and is often higher.

Front 32

acquired factor 8 inhibitor

Back 32

consider in pts with Bleeding symptoms and hematologic abnormalities in patients with autoimmune disorders, malignancy, or in the postpartum setting

Front 33

features of heriditary spherocytosis

Back 33

spherocytic red cells on the peripheral blood smear; a mild, Coomb's-negative, hemolytic anemia; and an elevated mean cellular hemoglobin concentration.

Front 34

treatment for myelofibrosis

Back 34

if young - stem cell transplant, if old- chronic transfusions

Front 35

clinical presentation of myelofibrosis

Back 35

Fatigue, weight loss, massive splenomegaly, and teardrop-shaped erythrocytes

Front 36

sxms of serotonin syndrome

Back 36

tachycardia, hypertension, hyperthermia, mydriasis, hyperactive bowel sounds, diaphoresis, hyperreflexia, clonus, and changes in mental status

Front 37

what is the complement pattern in active SLE?

Back 37

low C3, and to a lesser extent low C4

Front 38

hydroxychloroquine is associated with which kind of toxicity?

Back 38

retinal damage

Front 39

what cancer is increased and should be routinely screened for in patients that have been on cyclophosphamide>

Back 39

bladder CA - need UAs and cystoscopies

Front 40

stepwise Tx of RA?

Back 40

NSAIDs/pred-> DMARD once RA confirmed (MTX is preferred)-> anti TNF alpha. This is the same for psoriatic arthritis

Front 41

first line DMARD in SLE is?

Back 41

hydroxychloroquine - wary of retinopathy

Front 42

what is treatment for scleroderma?

Back 42

there is no disease-modifying Tx ; steroids can precipitate normo-tensive renal crisis

Front 43

polymyositis and/or dermatomyositis may have what classic Ab positive?

Back 43

Anti-Jo 1