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75 Cards in this Set
- Front
- Back
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pig-a gene
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paroxysmal nocturnal hemoglobinuria (PNH)
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Abnormal clones producing
PDGF / TGF-B / EGF |
myelofibrosis
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GPI Anchor
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anchors glycoproteins to cell membrane
part of pig-a gene [deffect in PNH] |
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markers to confirm AML
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CD 33/11/13/15/HLA-DR
[to help memorize 11-->13-->33] |
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t(15:17)
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RAR alpha --> APL
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drug to treat APL?
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ATRA
t(15:17) is considered a good prognosis |
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t(8:21)
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AML
good prognosis |
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inv(16)
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AML
good prognosis |
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t(8:14)
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Burkitt-like Lymphoma
inc c-myc |
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gene on chrom(8)
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c-myc
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t(12:21)
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ALL
good prognosis |
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gene on chrom(12)
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TEL
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gene on chrom(21)
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AML-1
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t(4:11)
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ALL
poor prognosis |
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t(8:2)
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burkitt lymphoma
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t(8:22)
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burkitt lymphoma
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gene on chrom(14)
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Ig heavy chain
Bcl-1 (inc cell proliferation) |
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t(11:14)
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mantle cell / B cell lymphoma
caused by inc Cyclin D1 |
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gene on chrom(11)
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cyclin D
propels cell through life cycle |
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"cold" antibody
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anti-CD20
Rituximab works on b cells |
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t(14:18)
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follicular lymphoma
bcl-2/IgH chimeric gene inc bcl-2 which prevents apoptosis |
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t(11:18)
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MALT (h pylori independant)
inc API-2 |
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t(1:14)
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MALT (h pylori independant)
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MIP-1
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inc RANKL and osteoclast activity
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CD markers for lymphocyte predominance
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+20 / -30 / -15
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CD markers for hodgkins
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-20 / +30 / +15
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treatment of hd
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ABVD
adriamycin / bleomycin / vinblastine / dacarbazine |
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Bcl-6
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diffuse large b cell lymphoma
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L3 ALL
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Burkitt
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t(4:14)
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myeloma
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FLT-3
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active prt kinase
No apoptosis poor AML |
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NPM1
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exon mutation
decr prot aggregation in nuc. Good AML |
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Hb f
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a2g2
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Hb H
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b4
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Hb Barts
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g4
no alpha globin loci... hydrops fetalis |
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Hb A2
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a2d2
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chrom (16)
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a globin
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chrom (11)
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b globin
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MCV
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hct/rbc count (80-100)
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MCH
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hb/rbc count (27-31)
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MCHC
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hb/hct
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section of GI where iron is absorbed
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duodenum / proximal jejunum
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glossitis
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smooth waxy tounge in fe deficiency
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b12 on cns
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affects myelin synth
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what molecule take b12 from ileum
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transcobalamin 2
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schilling test
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radioactive b12
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heinz bodies
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in g6pd def because oxidative stress denatures hb.
also found in hb h and those types |
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elt
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euglobulin lysis time
fibrynolysis |
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bleeding time
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platelet number and function
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lupus anticoag
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not assoc with bleeding
atibody bind to phospholipid reagents |
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desmopressin
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release all vwf from granules
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dense granules
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atp/adp
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alpha granules
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vwf, factor v, anti plasmin
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ITP
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immune thrombocytopenic purpura
Ig bound to platelet antigens |
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TTP
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Throbotic thrombocytopenic purpura
endo damage (perturbation) causes release of large vWF molecules. no vwf processing factors. diffuse platelet plugs |
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heparin Ig complex
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hep + PF4 bind. Ig made against complex.
bind platelet Fc receptor --> activate platelet to release PF4. endothelial damage |
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glanzmann
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defective gpIIIb-IIIa
no aggregation |
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storage pool def
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alpha granule def / dense granule def
chronic activation states reduced activation problem |
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ristocen
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test for vwf
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V quebec
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platelet alpha protein def
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LAD
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leukocyte adhesion def
no adhesion or rolling. no PMN at infections site |
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CGD
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no ndph --> no puperoxide.
mpo ok |
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mpo syndrome
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no mpo --> inc fungus
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cvid
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chronic variable immuno disease
affected Tcell/Ig normal b cell counts |
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Di george
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no thymus. immature t cells
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x linked agammaglobulinemia
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no bruton tyrosine kinase
only pre-b cells |
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hyper-igm syndrome
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no cd40l (t cells can't mediate isotype switching)
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scid
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severe combined immune def
no b/t (no maturation) |
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cd 5 marker on b cells
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b-cll/sll
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how to treat early malt...
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antibiotic for h pylori
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hypersensitivity III
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immune complexes
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hypersensitivity II
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complement
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Normal mch
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28-33
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hypersensitivity I
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IgE IL4
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meth-->heme
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cytochrome B5
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