Review Mtb

Front 1

Coagulopathy of Liver disease Deficiency and Tx

Back 1

Clotting factor - 2, 7, 9 . 10 and 5 with Fibrinogen
Tx: FFP and Chriopercipitate

Front 2

Vit K def Factors and Tx

Back 2

Factors - 2 7 9 10
Tx IV Vit K or Oral Vit K

Front 3

Protein C deficiency Presentation
Diagnostic test
treatment

Back 3

Skin necrosis with warfarin and thrombotic episodes
Protein C elvel deficiency
Heparin followed by Warfarin

Front 4

Lupus Anticoagulant or Anticardiolipin antibody
presentation
Daignostic test
Treatment

Back 4

Venous thrombosis, elvated aPTT with normal PT, Spontaneous Abortions and Flase VDRL
Mixing Study first and Russel viper venom test
Heparin followed by warfarin

Front 5

Factor V Leiden mutation
Presentation
Diagnostic test
Treatment

Back 5

Most common cause of thrombophilia - BLEEDING
Factor V mutation test
Heparin followed by Warfarin

Front 6

Antithrombin Deficiency
Presentation
Diagnostic test
Treatment

Back 6

Bleeding, no change in aPTT with a bolus of IV heparin
Level of antithrombin III
Large amount of heparin or direct thrombin inhibitor (Argatroban, lepirudin and Bivalirudin)

Front 7

When you cannot give Argatroban or Lepirudin for Percutaneous Coronary Interventions you give

Back 7

Bivalirudin

Front 8

Heparin- Induced Thrombocytopenia
Presentation
Diagnostic test
Treatment

Back 8

Drop in platelets, thrombosis most common clinical manifestation ( More venous than arterial)
ELISA for platelet factor 4 antibodies
Heparin-induced, antiplatelet antibodies
Stop Heparin and use direct thrombin inhibitors ( Argatroban, lepirudin and bivalirudin)

Front 9

Factor III - Deficiencies
Presentation
Diagnostic test
Treatment

Back 9

Joint bleeding or hematoma in male child
Mixing study first than specific factor levels
Severe deficiency - Factor VIII replacement
Minor deficiency - DDAVP (Desmopressin)

Front 10

Factor IX - Deficiencies
Presentation
Diagnostic test
Treatment

Back 10

Joint bleeding and hematoma but less common than factor VIII
Mixing study first than specific factor levels
Factor IX replacement

Front 11

Factor XI
Presentation
Diagnostic test
Treatment

Back 11

Rare bleeding with trauma and surgery
Mixing study first than specific factor levels
Fresh frozen plasma with bleeding episodes

Front 12

Factor XII
Presentation
Diagnostic test
Treatment

Back 12

No bleeding
Mixing study first than specific factor levels
No treatment Necessary

Front 13

Uremia-Induced Platelet dysfunction
Presentation
Diagnostic test
Treatment

Back 13

Normal platelet count with platelet-type bleeding in a patient with renal failure
Ristocetin test and VWF level will be normal
Desmopressin (DDAVP)

Front 14

Idiopathic Thrombocytopenic Purpura
Presentation
Diagnostic test
Treatmen

Back 14

Platelet type bleeding - Petechiae, Epistaxis, purpura, gingiva, gums and vaginal if the platelet is <50,000
Antiplatelet Antibody, Sonogram - to assess for normal spleen size. Bone marrow - Increaed numbers of megakaryocytes. Antibodies to the glycoprotein IIb/IIIa receptor
Platelet count > 50, 000 - not treatment
< 50,000 - Prednisone
< 20,000 - IGIG or Rogam
Chronic - Splenectomy if that does not work you can use Romplostim or eltrombopag

Front 15

Causes of Idiopathic thrombocytopenic Purpura

Back 15

Lymphoma
SLE
Infections - HIV or Hep C
MEDS

Front 16

Von Willebrand Disease
Presentation
Diagnostic test
Treatmen

Back 16

Bleeding from platelet dysfunction - Petechiae, Epistaxis, purpura, gingiva, gums and vaginal
aPTT can be elevated in 50% of the people