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49 Cards in this Set
- Front
- Back
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morphine
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less bioavailablity giv eIM or subQ or IV; gold std
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meperidine
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more potent than morphine; DOC for OB
build up of metabolite (normep) which causes T-C seizures w/ OD |
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which two drugs cause T-C seizures w/ build up of toxic metab?
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propoxyphene and meperidine
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which is opoid is the drug of choice for OB
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meperidine
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methadone
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better oral availablity than morphine; for opiod and heroin withdrawel
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which drug is given for withdrawel
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methadone
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fentanyl
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80x more potent than morphine; mm rigidity; has a path for chronic pain; IM/IV too
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which drug is available in a patch form for chronic pain?
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fentanyl
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oxycodone
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more oral bioavailablity; goo dw/ NSAID combo like percocet, oxycontin ect
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codein
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better oral avail; cough suppresive anti tussive; less abuse pot
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which two drugs have antitussive behaviors?
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codein and dextromethorphan
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propoxyphene
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less potent than codiene; oral; toxic metab-->T-C seizure; less abuse potetn b/c IV or SC
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buprenorphine
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partial agonist against mu; sublingual; longer than morphine; less resp effect less od; mu can precipitate withdrawel NOT in cardiac pt
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what is a mixed option and how is it given?
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parenterally; antag at mu and ag at kappa
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pentazocine
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mixed; w/ nalozone to prevent IV abuse
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nalbuphine
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no cardiac effect; mixed drug
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butorphonol
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nasal drug severe HA or addicts maintenance drug
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what drug is given nasally?
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butorphanol
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naloxone
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gold std to tx OD and neonatal resp distress; given to mom during labor; fatal if prematurely withdrawn b/c there is a short HL; parenteral
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what drug is given in drug OD?
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naloxone
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what does an opiod antagonist do?
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lbocks mu; no effect w/o opiods; can precipitate withdrawel no abuse
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natrexone
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inc oral availablility; opiod addicts; trasdermal; alcoholism; no euphoria if you drink
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what drug is given for alcoholics?
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natrexone; no eupohria
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dextromethorphan
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DM oral; good tussive little opiod and little abuse; rhobatussin
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diphenoxylate
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not water sol; antiAch muscrinic; prev abuse so oral; antidiarrheal
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loperamide
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imodium; no abuse; no tolerance; antidiarrheal
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2 antidiarrheal drugs
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loperamide and dipheoxylate
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enkephalins, B endorphins and dynorphine act on ______
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opiod recetpors
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why is there N/V in ambulatory pts?
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inc inner ear vestibular sn; lay down for relief
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some opiod SE
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miosis and resp depression, CV
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what NT do opiods release?
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DA
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what person is opiods CI in?
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pulmonary pts
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what phase 1 of clinical trials
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nl volunteers, det safety and pharmokinettics
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phase 2 of clinical trials
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small gp of pts w/ disease; dosage an defficacy
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phase 3 of clinical trails
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large trial w/placebo, stats of safety an defficacy
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phase 4 of clinical tirals
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post-marketing surveilance
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adulterated drugs are?
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do not meet stds of qulaity; contaminated, improper packaged, poor manufacturing
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label is false or has ommisions
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misbranded
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what law requires labeling?
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pure food and drug act
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what law has drug safety and started the orphan drug program
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provisions of the food, drug and cosmetic act
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give incentives to dev drugs for tx of rare disease?
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orphan drugs
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shedule 1 drugs
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high abuse pot; no medical use; heroin
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schedule 2 drugs
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high abuse potential, medical use; cocain, morphine, barbiturates
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elderly have reduced capacity to ___ drugs
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oxidize drugs in phase 1
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drug-induced fetal maformations is a concer when?
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4-10 wks of gestation (teratogenic drugs)
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what grade (S) have no risk to preg
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A, B and maybe C
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what grade (S) have risk to preg
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D, E and maybe C
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mixed opioid drugs SHOULD NOT BE USED IN ___ pts?
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cardiac
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which mixed drug has no sig cardiac effects?
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nabuphine
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