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62 Cards in this Set

  • Front
  • Back

Percentiles are __________ transformations of raw


z scores, t scores, and IQ scores.

Percentiles are non-linear transformations


unlike the other choices. That is, the amount of


raw score difference between 55%-60% does not


necessarily represent the same amount of raw


score difference as between 94%-99%.

In the circle of willis, the anterior communicating


artery bridges

the left anterior cerebral artery to the right


anterior cerebral artery

Posner and Petersons model of attention says


that the posterior attention system is responsible for _________; whereas the anterior attention


system is associated with ___________.

orienting and awareness of environment; signal


detection

most common neurologic manifestation of HIV

emotional lability and delirium associated with


HIV associated dementia

factitious disorder ?

Malingering is intentional and motivated by an


external reward. He is demonstrating a negative


response bias but not a positive one. While he


could be depressed, there is no evidence either


way. Factitious disorder is behavior motivated by


an intrinsic reward such as assuming the sick


role.

Standard Error of Measurement

- inversely related to the reliability of the test


- The standard dev must be known to calculate it


- confidence intervals based on the SEM assume


error distributions are normally distributed and


homoscedastic

amygdale play a crucial role in :

the perception of emotional cues and


production of emotional responses

What differentiates diencephalic amnesia from


bilateral temporal lobe amnesia?

Temporal ordering impairment

The striatum receives its blood supply from the

MCA and Lenticulostriate arteries

Statistical significance is

a direct function of sample size

if you placed a common object like a key or


pencil in the left hand of a typical


commissurotomy patient, out of sight of the


person, they

could recognize the object but not call out its


name



-The hemispheres cannot communicate in these


patients, making one hand unaware of what the


other is doing. And only input to the left


hemisphere (i.e. the right hand) would allow


verbal naming.

cortical blindness

Patients with cortical blindness may have


blindsight in which they still have some


perception outside of conscious awareness.


They can have anosognosia as in Anton’s


syndrome and be unaware of their deficit.


Answer C describes achromatposia (the world


seems drained of color) and Answer D is


incorrect as cortical blindness results from


total destruction of the primary visual cortex.

what most reliably distinguishes VaD from AD?

focal neuro findings and the presence of either


diffuse or focal cognitive findings

lesions causing achromatopsia often also cause

proposopagnosia


(both are caused by lesions on the fusiform gyrus


of the occipitotemporal cortex)

which thalamic nuclei is part of the visual


pathway

lateral geniculate nucleus

Specificity is ___________; while sensitivity is


__________.

true positive rate


true negative rate




* True positive: Sick people correctly diagnosed


as sick
* False positive: Healthy people incorrectly


identified as sick
* True negative: Healthy people correctly


identified as healthy
* False negative: Sick people incorrectly


identified as healthy
* True positive = correctly identified
* False positive = incorrectly identified
* True negative = correctly rejected
* False negative = incorrectly rejected

difficulty recalling events following and injury is


_______; while difficulty recalling previously


learned info because learning new info interfered


is called_________.

anterograde amnesia; retrograde interference

pairings of transmitters to nuclei

Basal Nucleus of Meynert and acetylcholine


Raphe nuclei and seretonin


Ventral tagmental area OR substantia nigra and


dopamine



The _________ pathway is involved with visual


perception of where objects are and the ________


pathway is involved with the visual analysis of


what objects are.

Dorsal (where)


Ventral (what)

Conduit d' approche

increasingly closer phonological approximates of


words

Math disorders

While inattention may be a cause of math


disorder as defined in the DSM-IV, sensory


neglect typically refers to a right parietal lesion


symptom in which material in one visual field,


usually the left, is ignored unless attention is


drawn to it.

difficulty performing math operations

anarithmetria


deficit knowledge of concepts in math is

acalculia with verbal deficits

difficulty organizing and manipulating numbers


spatially is

spatial dyscalculia

atrophy assoc with normal aging generally


reflects a loss of

myelin

what type of memory is recognizing a friend?

Recognizing a friend is best thought of as a


type of semantic memory, which is knowledge


acquired during one’s lifetime (Kolb and


Wishaw, 2003).



Tulving considered all knowledge which was


not autobiographical to be semantic


knowledge.



Episodic memory is singular events a person


recalls and is the other type of explicit memory


besides semantic.



Implicit memory unconscious and


nonintentional.

X linked adrenoleukodystrophy early cognitive


changes- what is most common?

visual perceptual px



This is a neurodegenerative condition seen in


children that typically involves cerebral


demyelination. Cognitive dysfunction is


generally correlated with the extent of white


matter changes on MRI. Hematopoetic stem


cell transplant is the most effective treatment.


Visual-spatial functioning is an excellent


predictor of neurocognitive function after stem


cell transplant for cerebral X-ALD.

The limbic system is important for ___________;


which involves the key structure____________.

homeostasis; hypothalamus

In LBD, Lewy Bodies

are found in nerve cells throughout the outer


layer of the brain (the cerebral cortex) and deep


inside the midbrain and brainstem.

In LBD,

parkinsonian Sx often not responsive to L Dopa

Wilson's disease

characterized by:


parkinsonian Sx


psychosis


hepatic dysfunction

supplemental motor area partial seizures often


include

fencing posture with extension of contralateral


upper extremity, tonic posturing, speech arrest,


and unusual sounds

dorsolateral frontal cortex

sequencing, persistence, switching

DBS for PD

effective in Tx rigidity but negatively impacts PS


and EF

most consistent NP finding seen in childhood


absence epilepsy is

visual memory deficits

initial Sx in Landau - Kleffner Syndrome

auditory agnosia

reduced IQ, optic pathway gliomas, decrease in


high signal intensity lesions on T2 weighted MRI


with increasing age?

NF 1

HD

every offspring has 50% chance of inheritance


IT 15 gene

Noonan syndrome

It is characterized by mildly unusual facial


characteristics, short stature, heart defects,


bleeding problems, and skeletal


malformations. Also bleeding disorders.



webbed neck


ptosis


hypertelorism


low set ears


high arched palate


lowered IQ but preserved verbal skills


found among girls and boys

marfan's syndrome

is a genetic disorder of human connective


tissue. It has various expressions ranging from


mild to severe: the most serious complications


are defects of the heart valves and aorta, which


often lead to early death. The syndrome also


may affect the lungs, eyes, dural sac


surrounding the spinal cord, the skeleton, and


the hard palate. People with Marfan tend to be


unusually tall, with long limbs and long, thin


fingers and toes.



caused by mutations in the FBN1 gene on


chromosome 15

What distinguishes PD from atypical


Parkinsonism?

PD responds to levodopa while atypical


parkinsonism does not

Sx of hydrocephelus

h/a


nausea


vomiting


cognitive impairment


papilldemia (decreased vision)

the most important factor to consider when


interpreting discrepancies between test scores in


children is

the base rate of the discrepancy

neglect is considered to be a failure to


respond/report or orient to novel stimuli

due to focal and possibly generalized lesions


involving right parietal/frontal lesions

Depression in PD

does not have a high remittance rate, tough to


treat


- it is unrelated to the severity of motor Sx


- it has a greater anxiety component


- it improves sig when Ldopa reduces disability


Wilsons disease has an early affinity for


degeneration on the ____________, resulting in


__________.

striatum, tremor

Kluver-Bucy syndrome

non aggressive beh, hyperorality,


hypersexuality



resulting from bilateral lesions of the anterior


temporal lobe (including amygdaloid nucleus).


Klüver–Bucy syndrome may present with


hyperphagia, hypersexuality, hyperorality,


visual agnosia, and docility.



list of symptoms differs somewhat by source.


Generally included are the following:



1. Amnesia. Characterised by an inability to


recall memories. Its nature is both anterograde


and retrograde, meaning new memories


cannot be formed and old memories cannot be


recalled. The level of amnesia is considered to


be profound.


2. Docility. Characterized by exhibiting


diminished fear responses or reacting with


unusually low aggression. This has also been


termed "placidity" or "tameness".


3. Dietary changes and/or Hyperphagia.


Characterized by eating inappropriate objects


(pica) and/or overeating.


4. Hyperorality. This was described by Ozawa


et al. as "an oral tendency, or compulsion to


examine objects by mouth".


5. Hypersexuality. Characterized by a


heightened sex drive or a tendency to seek


sexual stimulation from unusual or


inappropriate objects.[2][3][4]


6. Visual agnosia. Characterized by an inability


to recognize familiar objects or people.

a lesion in the right lateral geniculate nucleus of


the thalamus may cause

left homonymous field defects

motor neglect is characterized by

better movements in the ipsilateral rather than


contralateral space



reluctance to move limbs on the left (limb


akinesia or intentional neglect)



delay in initiating movement

Magnetic Resonance Spect

can be used to indirectly measure regional brain


activity during seizures and help localize their


region on onset

mood and motivational states can affect immune


status and appetite through connections with the

hypothalamus

population based norms for

making Dx of MR

Tourettes

presence of motor AND vocal tics by age 18


often co occurs with OCD


assoc with deficits in attn. and EF


pharm tx act on dopamine system

pituitary adenoma

most likely type of tumor to cause bitemporal


hemianopia

correlations btwn subjective mem complaints


and objective mem performance are low and

generally mediated by the patient's mood and


anxiety symptoms

Receiver operating characteristic curves (ROC)


used to

determine the diagnostic accuracy of a test or


to help determine which of 2 tests is more


accurate for diagnosing a certain condition



ROC analysis provides tools to select possibly


optimal models and to discard suboptimal


ones independently from (and prior to


specifying) the cost context or the class


distribution. ROC analysis is related in a direct


and natural way to cost/benefit analysis of


diagnostic decision making.

disorders of neuronal cell migration, such as


lissencephaly and polymicrogyria are often assoc


with

MR and seizures

The APO E4 gene

increases susceptibility to AD and LBD



is related to earlier onset of AD



does not reduce efficacy of acetylcholinesterase


inhibitor meds

posterior fossa syndrome following a resection


of a cerebellar tumor in childhood

features are mutism, ataxia, and emotional


lability

depression in PD

commonly seen:


anhedonia


apathy


sleep disturbence



less commonly seen:


suicide attempts

Lateral geniculate nucleus

is an oval body located at the termination of optic tract on each side of the brain and acts as


the primary relay center for visual information


received from the retina of the eye. The LGN and


the medial geniculate nucleus which deals with


auditory information are both thalamic nuclei


and so are present in both hemispheres

The Flynn effect

is the substantial and long-sustained increase


in both fluid and crystallized intelligence test


scores measured in many parts of the world


from roughly 1930 to the present day. When


intelligence quotient (IQ) tests are initially standardized using a sample of test-takers, by


convention the average of the test results is set


to 100 and their standard deviation is set to 15


or 16 IQ points. When IQ tests are revised, they


are again standardized using a new sample of


test-takers, usually born more recently than


the first. Again, the average result is set to 100.


However, when the new test subjects take the


older tests, in almost every case their average


scores are significantly above 100.