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11 Cards in this Set
- Front
- Back
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A 75-year old woman presents with flu-like symptoms of 1-week duration. She received a flu shot a few months ago. Her inability to clear this infection is most likely due to:
A. a superimposed bacterial infection B. age-related changes to her immune system C. an adverse reaction to the flu vaccine D. no prior immunologic experience with influenza E. selective IgA deficiency |
age-related changes to her immune system *
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The immune cell most involved in preventing infection of the respiratory tract is the:
A. B cell B. cytotoxic T cell C. dendritic cell D. eosinophil E. macrophage |
macrophage
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Your 41-year-old patient has chronic hypersensitivity pneumonitis, a disease characterized by chronic inflammation of the lung. Which of the following might you observe in a lung biopsy of this patient:
A. accumulation of surfactant in the alveoli B. apoptotic neutrophils D. histamine reactivity in the alveoli C. inducible bronchus-associated mucosal tissue E. Peyer’s patches |
inducible bronchus-associated mucosal tissue
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A 22-year-old man presents with fever and pneumonia-like symptoms. He has no history of hemoptysis or allergy. Surgical exploration and histopathology reveal that his lungs contain larval parasites (ex. human hydatidosis). The immune cell most able to clear this organism is the:
A. dendritic cell B. eosinophil C. neutrophil D. NK cell E. Th1 cell |
Eosinophils
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A lung biopsy of a patient with Goodpasture’s syndrome reveals diffuse alveolar hemorrhage. The immune mechanisms responsible for this pathology is:
A. autoantibodies against GM-CSF B. IgG binding to collagen type IV C. mannose-binding protein deficiency D. myeloperoxidase deficiency E. surfactant D inhibition of NFkB signaling |
IgG binding to collagen type IV
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Which of the following diseases results in susceptibility to recurrent or persistent respiratory infections, sinusitis and otitis media?
A. allergy B. asthma C. ciliary dyskinesia D. Goodpasture’s syndrome E. rheumatoid arthritis |
ciliary dyskinesia
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The inability to opsonise bakers' yeast (Saccharomyces cerevisiae) is a defect found in 5-7% of the general population and is thought to result from low levels of mannose-binding protein (MBP). This disease results in impaired activation of:
A. antibody-dependent cellular cytotoxicity B. classical complement pathway C. lectin complement pathway D. macrophages E. respiratory burst |
lectin complement pathway
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When pollen, a common allergen, enters the respiratory tract it is captured by:
A. cytotoxic T cells and a Th1 response is mounted B. dendritic cells and a Th1 response is mounted C. dendritic cells and a Th2 response is mounted D. macrophages and a Treg response is mounted E. NK cells and destroyed by antibody-dependent cellular cytotoxicity |
dendritic cells and a Th2 response is mounted
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A 4-year-old boy presents with his fourth upper respiratory tract infection of the year. His serum IgG, IgM and IgA levels in mg/dL are 383 (normal ~570-1300), 32 (normal ~30-160) and 12 (normal ~40-250), respectively. Which of the following is the most likely cause of his recurrent bacterial lung infections:
A. Goodpasture’s syndrome B. hypogammaglobulinemia associated with common variable deficiency C. leukocyte adhesion deficiency D. selective IgA deficiency E. Wiskott-Aldrich syndrome |
hypogammaglobulinemia associated with common variable deficiency *
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Hemophilus influenzae is a common cause of upper respiratory tract infections. The bacterium produces an IgA protease that:
A. blocks B cell production of IgA B. inhibits IgA-mediated complement activation C. interferes with bacterial motility D. prevents IgA from neutralizing extracellular bacteria E. prevents secretory component binding to dimeric IgA |
prevents IgA from neutralizing extracellular bacteria *
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A 40-year-old male smoker presents with dyspnea and a dry cough of 6-weeks duration. Rales are present and a histologic exam reveals alveoli filled with lipoproteins and fluid. The patient’s symptoms are most likely associated with a defect in GM-CSF binding to its receptor on the surface of a/an:
A. B cell B. dendritic cell C. eosinophils D. macrophage E. Th1 cell |
Macrophage
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