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13 Cards in this Set
- Front
- Back
Lipooxygenase Pathway
1)What product class is made? 2)Fxn of LTB4 3)Fxn of LTC4,D4,E4 |
1) Leukotrienes
2)Chemotaxis and adhesion 3)Bronchoconstriction,vasoconstriction, vascular permeability |
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Prostacyclin (PGI)
1)What enzyme made this? 2)What are the effects |
1) Cyclooxygenase
2) Decreases platelet aggregation, vascular tone, bronchial tone, and uterine tone (opposes TXA2) |
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Prostaglandins (PGE, PGF)
1)What enzyme made this? 2)What are the effects? |
1) Cyclooxygenase
2) Increase uterine tone, decrease vascular tone, decrease bronchial tone, Induce Fever (PGE) |
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Thromboxane (TXA2)
1)Where is this made? 2)What are the effects? |
1) Platelets make and release TXA2
2)Increase platelet aggregation, vascular tone, and bronchial tone |
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1st Generation Histamine blockers- Diphenhydramine (benadryl), dimenhydrinate
1)MOA 2)Use 3)Toxicity |
1) Blocks all H1 receptors to prevent Mast Cells release of histamine
2)Allergy, Motion Sickness, Sleeping Aid 3) Anticholinergic (leads to excess Sympathetics) Sedation (b/c excitatory paths in CNS are cholinergic) |
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2nd Gen Antihistamines- Fexofenadine (Allegra), Loratadine, etc
1)MOA 2)Use 3)Toxicity |
1)More selective blockade of histamine receptors
2)Allergy 3)Far less sedation, but can't be mixed with macrolides (Torsades de Pointe) |
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Asthma Treatment Strategy
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Beta Agonist (Specific and non-specific) to stimulate B2 and open airways
Methylxanthines to block cAMP breakdown -->bronchodilation Muscarinic Blockade- prevent ACh from stimulating bronchoconstriction Prevent Mast Cells from releasing leukotrienes and histamine Complete inhibit synthesis of Inflammatory mediators, or specifically block leukotriene synthesis |
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Beta Blockers for Asthma
1)Non-specific 2)Specific 3)Long Acting B2 |
1) Iosproterenol but it causes side effect of tachycardia
2)Albuterol is B2 only, and is used as a rescue medication 3)Salmeterol- long term prophylaxis but side effets are tremor and arrhythmia |
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Theophylline
1)MOA 2)Use 3)Toxicity |
1) Blocks Phosphodiesterase which breaks down the cAMP produced by B2 receptors --> prolongs bronchodilation
2)Asthma therapy 3)Narrow therapeutic index due to effect on heart and CNS |
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Ipatropium
1)MOA 2)Use 3)Toxicity |
1) Blocks Muscarinic Receptors to prevent ACh causing bronchoconstriction
2) Asthma |
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Cromolyn
1)MOA 2)Use |
1) Blocks release of histamine and leukotrienes from Mast Cells
2)Used in long term asthma control. Uneffective in acute asthma attack |
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Corticosteroids- Beclomethasone, Prednisone
1)MOA 2)Use 3)Toxicity |
1) Inhibits Phospholipase A2 --> prevents synthesis of Prostglandins, Leukotrienes, and NK-KB (normally activates TNF-alpha). Net effect is decreased inflammation
2) 1st line long term treatment of asthma 3) Cushings |
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Zileuton
1)MOA Zarfirlukast, Montelukast 2)MOA |
1) Blocks 5-lipooxygenase to specifically inhibit Leukotriene synthesis
2) Blocks Leukotriene receptors |