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23 Cards in this Set
- Front
- Back
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What drug relaxes smooth muscle but can cause tachycardia?
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isoproterenol (b2 relaxes bronchioles, b1 on heart)
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What drug is used during an acute asthma exacerbation to relax bronchial smooth muscle?
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albuterol
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What drug, used as prophylaxis, is associated with tremor and arrhythmia?
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Salmeterol
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What drug causes bronchodilation by inhibiting phosphodiesterase? What is increased by this inhibition?
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methylxanthines (theophylline)
cAMP levels increase bc drug blocks its hydrolysis by phosphodiesterase |
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What drug blocks muscarinic receptors in the bronchioles?
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muscarinic antagonists (ipratropium)
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What drug is used to treat COPD?
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Ipratroprium
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What drug is ONLY useful for prophylaxis of an asthma attack and CANNOT be used for an acute attack?
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cromolyn
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What drug blocks the release of mediators from mast cells?
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Cromolyn
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Narrow TI causing cardiotoxicity, vomiting, diarrhea, seizures, and neurotox icity are side effects associated with:
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Theophylline (methylxanthine)
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What drug blocks the conversion of arachidonic acid to leukotrienes?
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Zileuton (anti-leukotriene)
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What drugs blocks leukotriene receptors?
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zafirlukast, montelukast
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What drugs are good for aspirin induced asthma?
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Leukotriene receptor blockers- zafirlukast, montelukast
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What drugs inhibit synthesis of virtually all cytokine?
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corticosteroids (beclomethasone, prednisone)
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What drug inactivates NFkb?
What is NFkB? |
corticosteroids (beclomethasone, prednisone)
NfKB= transcription factor that induces production of TNFa, along with other inflamm agents |
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What drug class is the first line therapy for chronic asthma?
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STEROIDS
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What drug removes excess sputum but doesn't necessarily suppress the cough reflex?
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Guaifenesin (Robitussin)
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What drug is mucolytic?
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N-acetylcysteine
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What drug is used to loosen mucus plugs in CF?
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N-acetylcysteine
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What drug is an endothelin receptor antagonist?
What is it used for? |
Bostentin
to decreased pulmonary vascular vascocontriction in idiopathic pulmonary fibrosis |
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What are the second generation H1 blockers?
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Loratadine, fexofenadine, desloratadine, cetirizine
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What do 2nd generation H1 blockers cause less sedation?
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less CNS penetration
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What are some side effects associated with 1st gen H1 blockers?
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sedation, weight gain, dry mouth, orthostatic hypotension, etcccc
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Dephenhydramine, dimenhydrinate, chlorpheniramine, hydroxizine, promethazine
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What are the 1st gen H1 blockers?
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