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12 Cards in this Set
- Front
- Back
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H1 blockers
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1st - diphenhydramine, dimenhydrinate, chlorpheniramine
2nd - loratadine, fexofendadine, desloratadine, cetirizine |
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H1 blockers - 1st v. 2nd generation uses and SEs
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1st -- tx: allergy, motion sickness, sleep aid. se: sedation
2nd -- tx: allergy; se: less sedation (less CNS entry) |
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Nonspecific Beta agonist for asthma
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Isoproterenol (B1 and B2)
Tachycardia SE |
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Beta 2 agonists for asthma (2)
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Albuterol - acute exacerbation
Salmeterol -- long acting for prophylaxis. SE: tremor, arrythmia |
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Theophylline
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Methylxanthine tx for asthma, rarely used due to cardio/neurotoxicity/P450.
Bronchodilation by inhibiting PDE and adenosine (increases cAMP and decreases adenosine-induced bronchoconstriction) |
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Ipratropium
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Muscarinic antagonist, prevents bronchoconstriction
Tx: Asthma, COPd |
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Cromolyn
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Prevents release of mast cell mediators
Only for PROPHYLAXIS of asthma. Not useful during acute attack. |
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Beclomethasone, prednisone
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CSs used as 1st line for asthma. Inhibits cytokine synthesis by inactivzting NF-kB (txn fx for TNF-alpha and others).
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Zileuton
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Antileukotriene for asthma
5'-lipooxygenase pathway inhibitor. Blocks conversion of AA --> LTs. |
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Zafirlukast, Montelukast
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Antileukotriene for asthma
Blocks LT receptors. Great for ASA-induced asthma. |
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Expectorants (2)
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Guaifenesin (removes sputum, does not suppress cough)
NAC (CF pts and acetaminophen OD) |
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Bosentan
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Pulmonary HTN tx.
Blocks endothelin-1 receptors. (Endothelin1 = potent vasoconstrictor) |
