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27 Cards in this Set
- Front
- Back
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Short Acting B2 agonist
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MAST
Salbutamol Albuterol Terbutaline Metaproterenol |
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Long acting B2 agonist
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FS - meterol
Salmeterol Formeterol |
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use of short acting B2 agonist
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symptomatic asthma relieve - acute management
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use of long acting B2 agonist
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prophylaxis
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MOA of B2 agonist
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Stimulation of B2 receptors activates Gs increase cyclic AMP leading to decrease muscle tone – bronchial smooth muscle relaxation
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ADR of B2 agonist
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Fine tremors (of the fingers of the hand)
Palpitations Dizziness Restlessness Agitation FDRAP |
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MOA of steroids
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Inhibit Phospholipase A
DO NOT CAUSE RELAXATION |
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ADR of steroids
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Dysphonia and Oral candidiasis
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How can you prevent the ADR of steroids
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It can be prevented by advising the Pts to gargle the mouth with saline water
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Name Leukotriene Receptor Blockers
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Montelukast
Zafirlukast ..KASt |
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Leukotriene Synthesis Inhibitors
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Zileuton
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MOA of leukotrienes Synthesis Inhibitor
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blockage of LOX enzyme
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MOA of Leukotriene Modulators
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They act by antagonizing the actions of Leukotrienes
Inhibit bronchoconstriction Decrease microvascular leakage and mucus production They inhibit the influx of basophils and lymphocytes into the airways |
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use of leukotrienes modulators
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Used in treatment of mild to moderate asthma for prophylaxis
Used in combination with Beta Agonists and Glucocorticoids |
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MOA of Leukotriene Receptor Blockers
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blocks leukotrienes and prevents bronchoconstriction
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Name 2 PDE inhibitors and note difference
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Viagra - inhibits PDE5 increasing cGMP
Xanthine - inhibits PDE increasing c AMP |
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Xanthine derivatives
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Theophylline ( Clinically used)
Theobromine Caffeine |
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muscarinic receptor blocker
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Ipratropium
Oxitropium Tiotropium |
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Names of anticholinergics used in Asthma and COPD
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Ipratropium, Oxitropium, and Tiotropium
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increase the mucociliary clearance
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anticholinergics
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Mast Cell Stabilizers
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Sodium cromoglicate
Nedocromil Sodium |
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Mode of action of mast cell stabilizers
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stabilizing the mast cell from degranulation and inhibiting the further release of inflammatory mediators from the mast cell
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DOC status asthmaticus
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Adrenaline
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Names and ADR of inhaled steroids
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BBFM
Beclomethasone, Mometasone, Flunisolide, and Budesonide ADR: dysphonia and oral candidiasis |
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Names of antitussives and their MOA
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Opioids: Codeine, Pholcodeine, and Morphine
-Nonopioids: Noscapine and Dextromethorphan -Antihistamines: Promethazine, Chlorpheniramine and Diphenhydramine -MOA: suppress medullary cough center |
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Expectorants/mucolitics
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Guaiphenesin
Bromhexine Carbocysteine |
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MOA Expectorants/mucolitics
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Acts by increasing tracheobronchial secretions or breaks the disulfide bonds in the vicid mucus
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