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24 Cards in this Set

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  • Back
Partial Pressure of oxygen
PO2= Pb x Fo2= barometric pressure x fractional component of oxygen
What causes right shift of oxygen-hemoglobin dissociation curve?
Increased: CO2, temp, 2,3-DPG
Decreased: pH
What causes left shift of oxygen-hemoglobin dissociation curve?
Increased: pH
Decreased: CO2, temp, 2,3-DPG
Central Chemoreceptors
decrease in pH of brain ECF
Peripheral chemoreceptors
decrease in arterial PO2
Stretch Receptors
stretch of lungs during inflation
Irritant Receptors
alergen,lung inflammation, histamines
Pulmonary C Fibers
interstitial pulmonary edema
Nasal, Laryngeal, and Pharyngeal Receptors
mechanical and chemical irritants
Jonint and Muscle Receptors
Limb Movement
No ventilation
Decrease in V/Q to 0
V/Q is about 1
No Perfusion
Increase in V/Q to infinity
Bohr Effect
When pH of blood decrease, there is a decrease in the affinity of hemoglobin for oxygen-> release of oxygen
Haldane Effect
The release of oxygen form the heme portion of hemoglobin increases the affinity for CO2-> pick-up CO2
Haldane Effect
When the pH of blood increases, there is a decrease in the affinity of hemoglobin for carbon dioxide
Medullary Respiratory Centers
Brainstem- generate basic rhythmic pattern
Pontine Resp. Cntrs
Brainstem-pneumotaxic and apneustic centers
Pneumotaxic Center
switch off the inspiratory neurons
Apneustic Center
Prevent inspiratory nerons from being switched off
modifies the activity of brainstem neurons-alters breathing
Zone 1
PA>Pa>Pv -> no blood flow-ventilated, not perfused
Zone 2
Pa>PA>Pv -> as pressure difference increases toward bottom, blood flow will increase
Zone 3
Pa>Pv>PA -> capillaries are permentently opened