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15 Cards in this Set
- Front
- Back
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Aspergillus is frequently encountered in what type of patient?
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IMMUNOCOMPROMISED! cancer, transplant, HIV, neutropenia, macrophage dysfunction, CF patients
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What is the primary strain of Aspergillus infection?
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fumigatus (90% of infections are this strain)
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Aspergillus is very dangerous because it is non-dimorphic. What does this mean?
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Aspergillus grows mold at 37 degrees C. This means that when it gets into your lungs, it does not grow as a yeast, it sprouts mycelia.
but note: in the non-immunocompromised pt it would not do as much because it is not dimorphic |
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What are the three different disease forms associated with Aspergillis infection?
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Allergic/Inflammatory (ABPA), Colonizing (aspergilloma), Invasive
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ABPA stands for what? What is it and who does it affect?
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Allergic bronchopulmonary aspergillosis (ABPA) is an immune hyper-reactivity reaction wtih immediate and delayed responses
It is frequently seen in corticosteroid dependant patients (those with asthma), pre-existing asthma and cystic fibrosis |
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How can we identify allergic bronchopulmonary aspergilliosis?
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there are 7 ways, but the one he talked about the most was idenfitication of hyphae in the sputum (he was pretty excited that the hyphae branch at 60-70 degrees)
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Which pathologic meghanism is the most commonly seen in aspergillus infection?
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aspergilloma-- this is because it is what can affect a normal immune system as well as an immunocompromised one
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What is an aspergilloma? where are they most likely seen?
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A fungus ball.
Aspergillomas are mostly commonly seen where there is scar tissue already present (like in cystic fibrosis, TB and sarcoidosis) note: this is what prevents the immune system from being able to destroy them, they are protected by the scar tissue |
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What is the most serious complication of aspergillus infection?
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Invasive Pulmonary Aspergillosis
note: it can spread to other organ systems |
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If you see a halo sign on an x ray of someone with an aspergillus infection, which manifestation is it?
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Invasive pulmonary aspergillosis
note: the halo sign is a ring of air forming around the aspergilus |
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Rhizopus and Mucor are the causative agents of what?`
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Zygomycosis
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What is the main predisposing factor for zygomycosis (fungal infection)?
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Diabetic ketacidosis
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Your basement flooded. What fungus would you most likely see?
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Stachybotrys cartrum
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what is sick building syndrome?
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when fungus grows in your A/C unit, leading to multiple people in one building becoming ill
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pt presents to your office with allergy like symptoms. After taking a stellar history because you went to WVSOM, you discover that this pt is a grain worker. You explain to him that what he is experiencing are allergies due to what? Your fellow fledgling medical student from another school tries to pimp you and asks what immune response is controlling his reaction. You laugh and say...?
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grain worker => Aspergillus fungal infection
IgE mediates that you punk ass student. Go back to the Caribbean |
