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15 Cards in this Set
- Front
- Back
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ADR’s
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arise from properly administered drugs
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ADEs
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from administration error
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CYP2C9 (P450) enzyme
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- is only 10% normal activity
- some people have a mutant of this and they will not metabolize warfarin as well |
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a b2 mutation
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(Arg16Gly) is associated with rapid downregulation
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a b1 polymorphism
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- homozygous Arg at position 389
- is associated with increased coupling to Gs and clinical hypertension |
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steep dose-response curves
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common in cardiac glycosides
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drugs affect by age
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- 1/2 life increases
- Aminoglycosides (big time), Diazepam, and Thioridazine |
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drugs that are hard to take w/ disease and non-compliance
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Benzodiazepines, Phenothiazines, Digoxin, NSAIDS
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Cytotoxic reactions
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Hepatic Toxicities of Isoniazid, Acetaminophen
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Immunological reactions
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Penicillin Hypersensitivity
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what is the p450 of warfarin
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2C9
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OTC drugs positives
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- can provide safe, effective, inexpensive therapy
- (famotidine, fexofenadine, terbinafine) |
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OTC drugs negatives
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1) can be dangerous to certain populations or can interact with prescription drugs
2) OTC preparations often contain “hidden ingredients” (eg acetaminophen, alcohol, antihistamines) |
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Herbal durgs positives
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- may provide therapeutic benefits in some cases
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Herbal durgs negatives
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1) current preparations are heterogeneous and not standardized
2) Some risk of direct adverse reactions 3) considerable risk of adverse interactions with prescription drugs |
