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14 Cards in this Set

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Rx for acute exacerbation of asthma
Albuterol - beta 2 agonist - bronchial relaxation
Long acting agent for asthma prophylaxis
SE
Salmeterol - beta agaonist
SE - tremor and arrhthmia
Ipratroprium
competitive musc block - prevents bronchoconstriction
Cromolyn
prevents mast cell degranulation
Effective only for asthma prophylaxis
Not effective in acute attack
1st line therapy for chronic asthma
Beclomethasone, prednisone
Inhibits synth of almost all cytokines,
Inactivates NF-kB (tf for TNF-alpha)
Zileuton
Zafirleukast
Zileukton - inhibits 5-lipoxygenase
Zafirleukast - blockes leukotriene rec
For asthma prevention
Theophylline
causes bronchodilation by inhibiting phosphodiesterase -> incr cAMP. Narrow therapeutic index.
Receptors
alpha1, M1, M3, H1, V1
Gq receptor
PLPC -> PIP2 -> IP3 + DAG
IP3 -> incr intracell Ca
DAG -> inc PKC

M1 -CNS
M3 - incr exocrine gland secr, bronchoconstriction, vasodilation (and reflex tach)
H1 - incr nasal and bronchial mucus, contraction of bronchioles, pruritis, pain
V1 - incr vasc smooth muscle contraction
Gq receptor
alpha1, M1, M3, H1, V1
PLPC -> PIP2 -> IP3 + DAG
IP3 -> incr intracell Ca
DAG -> inc PKC
Rec
Beta1,2
D1
H2
V2
Gs receptor
Adenylcyclase ->ATP -> incr cAMP -> incr PKA

Beta1: incr- HR,contractility, renin rls, lipolysis, aqueous humor formation
Beta 2: vasodilation, bronchodilation, incr glucagon rls
D1: relaxes renal vasc smooth muscle
H2: incr gastric acid secr
V2: incr H20 perm and resorption in collecting tubules of kids
Gs receptor
Beta1,2, D1, H2, V2
Adenylcyclase ->ATP -> incr cAMP -> incr PKA
Rec
Alpha 2, M2, D2
Gi receptor
Adenycyclase (inhibit) -> decr cAMP -> decr PKA

M2: decr HR
D2: modulates NT rls, esp in brain.
Gi receptor
Rec
Alpha 2, M2, D2
Adenycyclase (inhibit) -> decr cAMP -> decr PKA
TB drugs
rifampin, INH, ethambutol/streptomycin, pyrazinamide,