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14 Cards in this Set
- Front
- Back
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Rx for acute exacerbation of asthma
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Albuterol - beta 2 agonist - bronchial relaxation
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Long acting agent for asthma prophylaxis
SE |
Salmeterol - beta agaonist
SE - tremor and arrhthmia |
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Ipratroprium
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competitive musc block - prevents bronchoconstriction
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Cromolyn
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prevents mast cell degranulation
Effective only for asthma prophylaxis Not effective in acute attack |
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1st line therapy for chronic asthma
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Beclomethasone, prednisone
Inhibits synth of almost all cytokines, Inactivates NF-kB (tf for TNF-alpha) |
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Zileuton
Zafirleukast |
Zileukton - inhibits 5-lipoxygenase
Zafirleukast - blockes leukotriene rec For asthma prevention |
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Theophylline
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causes bronchodilation by inhibiting phosphodiesterase -> incr cAMP. Narrow therapeutic index.
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Receptors
alpha1, M1, M3, H1, V1 |
Gq receptor
PLPC -> PIP2 -> IP3 + DAG IP3 -> incr intracell Ca DAG -> inc PKC M1 -CNS M3 - incr exocrine gland secr, bronchoconstriction, vasodilation (and reflex tach) H1 - incr nasal and bronchial mucus, contraction of bronchioles, pruritis, pain V1 - incr vasc smooth muscle contraction |
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Gq receptor
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alpha1, M1, M3, H1, V1
PLPC -> PIP2 -> IP3 + DAG IP3 -> incr intracell Ca DAG -> inc PKC |
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Rec
Beta1,2 D1 H2 V2 |
Gs receptor
Adenylcyclase ->ATP -> incr cAMP -> incr PKA Beta1: incr- HR,contractility, renin rls, lipolysis, aqueous humor formation Beta 2: vasodilation, bronchodilation, incr glucagon rls D1: relaxes renal vasc smooth muscle H2: incr gastric acid secr V2: incr H20 perm and resorption in collecting tubules of kids |
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Gs receptor
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Beta1,2, D1, H2, V2
Adenylcyclase ->ATP -> incr cAMP -> incr PKA |
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Rec
Alpha 2, M2, D2 |
Gi receptor
Adenycyclase (inhibit) -> decr cAMP -> decr PKA M2: decr HR D2: modulates NT rls, esp in brain. |
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Gi receptor
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Rec
Alpha 2, M2, D2 Adenycyclase (inhibit) -> decr cAMP -> decr PKA |
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TB drugs
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rifampin, INH, ethambutol/streptomycin, pyrazinamide,
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