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20 Cards in this Set
- Front
- Back
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what is primary/secondary ciliary dyskinesia?
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defect in the action of the cilia lining the respiratory tract
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this often diminishes in the elderly and is due to the stimulation of irritant receptors. It involves high pressure forced expiration
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the cough reflex
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where are macrophages in the respiratory tract?
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alveolar spaces
along the large and small airways beneath the mucous lining interstitial basically all over |
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what are the 3 major functions of macrophages?
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phagocytosis, antigen presentation, cytokine production
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where are monocytes located?
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IN THE BLOOD
can enter a cell and become a macrophage |
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diff btw dendritic cell and macrophage?
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dendritic: primary roll is antigen presenting cell, to activate an antigen specific immune system (T cells)
macrophages: have the machinery for antigen presentation, but primary function is phagocytosis |
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The mucosal immune system is functionally divided into 2 parts..they are?
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1. Follicles (predominantly B cells)
2. Diffuse Cells throughout the respiratory tract |
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what is the function of the mucosal lamina propria?
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cells can come out of the vasculature and get into the mucosal layer
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on mucosal membranes, what antibody do you normally find?
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secretory IgA
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The mucosal immune system is functionally divided into 2 parts.... this part is considered the "afferent region" where antigens enter and induce immune responses
what division is this? |
Follicle
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The mucosal immune system is functionally divided into 2 parts....this part is considered the "efferent region" where antigens interact with differentiated (memory) cells and cause the secretion of antibody by plasma cells or induce cytotoxic reactions by
T cells |
Diffuse
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what joins sIgA dimers?
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J Chain
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why secretory IgA named as such?
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it acts as a transporter for IgA molecules to get from the lamina propria area, across the epithelial cells and to the mucosal lumen, and also makes the sIgA less vulnerable to proteolytic digestion.
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What sort of clinical presentations might you expect from patients with severe deficiency of IgA antibody?
Why? |
Most people with this problem will never present to a physician because they don't have clinical problems!
the immune system compensates and increases production of IgG and IgM (IgM can be transported to the mucosal lining, just not as efficiently) |
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what 4 respiratory defenses seem to go down with age?
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Immune cell activation
Response to vaccines Mucociliary clearance Cough reflex |
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check out the objectives to make sure you hit everything...you were taking notes...but the lecture was kinda thin...
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just do it. then delete this card. stop complaining
Love, past Ryan |
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What 3 cells are used for anti-viral defenses?
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Type I interferons,
NK cells, CD8+ T cells |
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what 3 cells are used for anti-fungal defense?
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Th1 T cells
Macrophages Neutrophils |
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What 2 cells are used for anti-parasitic defense?
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Eosinophils
IgE |
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How might tobacco use or influenza infection affect mucosal defenses?
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it will impair the ability of ciliated mucosa to push mucus and unwanted substances out of the resp tract
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