Resp 2D

Front 1

What stimulates the secretion of surfactant.

Back 1

1) high volume lung inflation 2) increased ventilation rate 3) endocrine stimulation

Front 2

How is surfactant removed?

Back 2

Exocytosis into alveolar macrophages and type II epithelia cells. Then recycled.

Front 3

Describe the composition of surfactant/surfactant layer

Back 3

90% lipid, mostly phospholipid. May be mono or multilayer.

Front 4

Describe SP-A

Back 4

Surfactant protein A. Large glycoprotein, controls secretion/reabsorption of surfactant, prevention of infection

Front 5

Describe SP-B

Back 5

Surfactant protein B. Small, hydrophobic protein that can be incorperated into the phospholipid layer for stabalization

Front 6

Describe SP-C

Back 6

Surfactant protein C. Larger protein spans a lipid bilayer. Creates a resivoir from which surfactant can re-form.

Front 7

Describe SP-D

Back 7

Surfactant protein D. Like A (large, control of secretion/absorption, immunity)

Front 8

Describe IRDS

Back 8

Infant Respiratory Distress Syndrome. Caused by deficiency of surfactant -> atelectasis -> increased work of breathing. Tx'd w/ glucocorticoids.

Front 9

Describe the effects of surfactant on pulmonary filtration

Back 9

Prevents transudation

Front 10

What are problems w/ the bubble model?

Back 10

1) liquid is continuous b/t alveoli, so theoretically the tensions of adjacent alveoli cannot be different 2) When alveoli are compressed, they can form 'dry rafts' of surfactant 3) Alveoli are not spheres