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13 Cards in this Set
- Front
- Back
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3 anatomic host defense systems for respiratory
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upper airway
epiglottis/larynx epithelial joint junctions |
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How does turbulent flow help the airway?
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displaces large particles to prevent passage into trachea
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Most common size of aerosolized meds
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1-4 microns (bc higher percentage of pulmonary deposition
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What is affects by acid aspiration?
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epithelial tight junctions
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Secretions in bronchus that inhibit bacterial growth
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IgA, lysozyme, lactoferrin
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Which mechanism can PCD pts use that CF pts can't necessarily use?
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Controlled cough clearance.
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Location of motile cilia
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brain (ependymal), reproductive tract (fallopian tube, sperm flagella), airways (respiratory)
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What is missing in PCD?
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either outer dynein arm, inner dynein arm, or both
AR (obviously many genes) |
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3 possibilities of Thoraco-Abdominal asymmetry
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situs solitus
situs inversus totalis heterotaxy (situs ambiguus) |
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Common co-presentation of congenital heart disease
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heterotaxy
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Immune secretions for lung defense
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innate (lysozyme, lactoferrin)
Immune response (IgA, humoral Ab, cellular) |
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Describe role of IgA deficiency in chronic respiratory infection.
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not always the cause, IgA def often caused by def in IgG-2 and IgG-4
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3 general defenses within alveoli
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Alveolar macrophages (AM)
inflammatory response (PMNs) Anti-proteases (alpha1-antitrypsin def) |
