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15 Cards in this Set
- Front
- Back
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What Herpes Simplex Virus Serotype causes the majority of STDs?
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Type 2
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What cell type does HSV infect during primary disease period?
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Epithelial cells (cutaneous and/or mucocutaneous)
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What are the symptoms associated with primary HSV disease
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painful blister-like lesions in the genital region
systemic symptoms: fever, chills, malaise inguinal lymphadenopathy dysuria and urinary retention Note: often can be asymptomatic |
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What is the mean duration of virus shedding during primary disease of HSV?
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12 days.
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Give two differential diagnoses for the warts that are seen with HSV STD infection?
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Syphilis
Chancroid |
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Is the recurrent disease stage of an HSV infection usually more or less severe than the primary disease?
What is the mean shedding period? |
LESS! Often can be completely asymptomatic.
Mean shedding period is 8 days |
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What is Mollaret's Meningitis a complication of?
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HSV infection and recurrence
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Why is it that HSV is a lifelong infection, despite the body creating antibodies against the disease?
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Because the virus goes through a latency period between active infection within peripheral nerves and sacral ganglion.
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What causes HSV to be essentially "turned off" during the latency phase?
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Neuronal methylation
Heterochromatic Chromosomal tethering that limits gene expression |
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When a nerve harboring a latent HSV infection is stimulated, what happens to stimulate virus production?
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Chromatin gets converted and the tethered viral genome becomes euchromatic.
Neuronal demethylation |
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What component of the HSV genome protects nerve cells from being apoptosed during active infection?
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miRNAs/siRNAs
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Where are most cases of neonatal herpes acquired?
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In the birth canal (90%)
Mother is usually asymptomatic and unaware of the infection. |
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Which HSV infection is a TORCH entity?
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HSV Type 2
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Is the risk of neonatal HSV infection greater in a mother with primary infection or recurrent infection?
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Primary.
Also usually causes more severe disease in the neonate |
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What are the 3 clinical patterns seen in neonatal HSV 2 infection?
What major issue is seen in most survivors of neonatal HSV by age 1? |
SEM: skin, eyes, mouth
CNS: encephalitis Disseminated --> MOST SEVERE. 85% mortality if untreated Cognitive impairment |
