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52 Cards in this Set
- Front
- Back
|
Leuprolide
mech |
GnRH analog (hypothalamus)
pulsatile - agonist continuous - antagonist |
|
|
leuprolide
use |
infertility (pulsing)
uterine fibronoids prostate cx (continuous - use with flutamide) |
|
|
flutamide
use |
prostate cancer
|
|
|
methyltestosterone
use |
hypogonadism
development of 2ndary sex character burns - stimulate anabolism ER-+ breast cx |
|
|
methyltestosterone
se |
masculinized females
decrease LH -> decrease intratesticular testosterone -> gonad atrophy premature epiphyseal plate closure high LDL low HDL |
|
|
finasteride
mech |
5-alpha reductase inhibitor
|
|
|
finasteride
uses |
BPH
hair loss |
|
|
flutamide
mech |
nonsteroidal competitive inhibitor of androgens at testosterone R
|
|
|
ketoconazole
mech |
inhibit steroid synthesis
inhibit desmolase |
|
|
ketoconazole
use |
polycystic ovarian syndrome
- prevent hirsutism |
|
|
ketocanozole
se |
gynecomastia
amenorrhea |
|
|
spironolactone
mech |
inhibit steroid binding
|
|
|
spironolactone
use |
polycystic ovarian sx
|
|
|
spironolactone
se |
gynecomastia
amenorrhea |
|
|
estrogen
drugs |
ethinyl estradiol
DES mestranol |
|
|
ethinyl estradiol, DES, mestranoluse
|
hypogonadism
ovarian failure menstrual abnormalities menopause men-androgen dependent prostate cx |
|
|
ethinyl estradiol, DES, mestranol
se |
endometrial cx
bleeding clear cell adenocarcinoma of vagina (if exposed to DES in utero) thrombosis contraindicated: ER+ breast cx, prior DVT |
|
|
clomiphene
mech |
hypothalamic estrogen R partial agonist
LH/FSH increase--> ovulation |
|
|
clomiphene
use |
infertility
PCOS |
|
|
clomiphene
se |
hot flashes
ovarian enlargement multiple preggers visual problems |
|
|
tamoxifen
mech |
estrogen antagonist on breast estrogen R
|
|
|
tamoxifen
use |
ER+ breast cancer
|
|
|
raloxifene
mech |
estrogen agonist on bone
reduce bone resorption |
|
|
raloxifene
use |
osteoporosis
|
|
|
hormone replacement therapy
use |
relief/prevent menopause sx
osteoporosis |
|
|
hormone replacement therapy
se |
endometrail cx
(use progesterone to prevent) cardiovascular probs |
|
|
anastrozole
mech |
aromatase inhibitor
|
|
|
anastrozole
use |
postmenopausal women with breast cx
|
|
|
exemestane
mech |
aromatase inhibitor
|
|
|
exemestane
use |
postmenopausal women with breast cx
|
|
|
progestin
mech |
progesterone R agonist
reduce growth of endometrium increase vacularization of endometrium |
|
|
progestin
use |
OC
endometrial cx abnromal uterine bleeds |
|
|
mifepristone (RU486)
mech |
progesterone competive inhibitor at R
|
|
|
mifepristone
use |
terminate pregnancy (+misoprostal - prostaglandin e1)
|
|
|
mifepristone
se |
bleeding
gi - N/V anorexia |
|
|
OC
mech |
progestin and estrogen prevent estrogen surge and LH surge so no ovulate
|
|
|
OC
advantage |
less endometrial/ovary cx
less ectopic preg less pelvic infxn |
|
|
OC
disadvantage |
triglycerides
depression/weight gain/N hypercoaguable |
|
|
dinoprostone
mech |
prostaglandin e2 analog
cervical dilation uterine contraction |
|
|
dinoprostone
use |
induce labor
|
|
|
ritodrine
mech |
b2-agonist
relax uterus less contraction |
|
|
ritodrine
use |
prevent early delivery
|
|
|
terbutaline
mech |
b2-agonist
relax uterus so no contract |
|
|
terbutaline
use |
prevent early delivery
|
|
|
tamsulosin
mech |
selective alpha1a,d receptor (on prostate)
not alpha1b receptor (on vessels) |
|
|
tamsulosin
use |
BPH
inhibit smooth muscle contraction |
|
|
sildenafil
mech |
inhibit cGMP phosphodiesterase
more cGMP smooth muscle relax in corpus cavernosum |
|
|
sildenafil
use |
erectile dysfxn
|
|
|
sildenafil
se |
headache
heartburn hypotension (contraindicated: nitrates) blue-green color blind |
|
|
vardenafil
mech |
inhibit cGMP phosphodiesterase
more cGMP relax corpus cavernosum smooth m |
|
|
vardenafil
use |
erectile dysfxn
|
|
|
vardenafil
se |
headache
heartburn hypotension (contraindicated: nitrates) blue-green color blind |
