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17 Cards in this Set
- Front
- Back
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Finasteride =
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5a-reductase inhibitor - BPH, male pattern baldness
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Flutamide =
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competitive testosterone receptor inhibitor - prostate CA
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Ketoconazole =
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inhibit steroid synthesis - prevents hirsutism in women w/polycystic ovaries
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Spironolactone =
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inhibit steroid synthesis - prevents hirsutism in women w/polycystic ovaries
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Mechanism of axn of Sildenafil & Vardenafil:
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inhibit cGMP phosphodiesterase --> inc. level cGMP --> SM relaxation, inc. blood flow, erection
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Toxicities of Sildenafil & Vardenafil:
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- HA
- flushing - dyspepsia - BLUE GREEN color vision! - dangerous HYPOtension in patients also taking nitrates! |
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Leuprolide =
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GnRH analog
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How do you give Leuprolide in the treatment of infertility?
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pulsatile doses
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How do you give Leuprolide in the treatment of prostate CA?
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give continuously (in addition to Flutamide)
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How do you Tx leiomyomas (uterine fibroids)?
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Leuprolide
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Besides Leuprolide, what else can you give for infertility?
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Clomiphene - partial estrogen receptor agonist in pituitary --> inc. release of LH & FSH --> stimulate ovulation
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What are side effects of Leuprolide?
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nausea/vomiting, antiandrogen effects
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What are side effects of Clomiphene?
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hot flashes, enlarged ovaries, multiple simultaneous pregnancies (O_o), visual disturbances
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Mifepristone (RU-486) is used for:
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competitive inhibitor of progestins - prevents implantation, abortion (of pregnancy < 49 days' duration)
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How reliable are oral contraceptives?
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Very reliable, < 1% failure
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Oral contraceptives and risk of endometrial & ovarian cancer: increased/decreased/no effect
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DECREASE!
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What are some disadvantages of oral contraceptives?
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- take daily
- hypercoagulable state!!! - raise TGs - no protection against STDs (duh) - depression, wt. gain, nausea, HTN |
