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18 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Leuprolide
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GnRH analog acts as agonist with pulsatile administration and antagonist with continuous
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Use: Infertility, prostate cancer, uterine fibroids
Toxicity: anti-androgen, nausea, vomiting |
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Testosterone
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agonist at androgen receptors
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Use: treat hypogonadism and promote seondary sex characteristics
Toxicity: masculinization in females, decreased intratesticular testosterone because of negative feedback-->gonadal hypertrophy, premature closure of epihphyseal plates. increases LDL |
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finasteride
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anti-androgen, blocks 5alpha reductase, useful for BPH, promotes hair growth
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Use: prevents mall patterned hair loss and encourages female breast growth
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flutamine
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a nonsteroidal competitive androgen antagonist
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Use: prostate carcinoma
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ketoconazole
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inhibits desmolase and decreases steroid synthesis
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Use: PCOS and prevent hirsuitism
Effects: gynecomatia and amenorrhea |
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sprionolactone
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inhibits steroid binding
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Use: PCOS and prevent hirsuitism
Effects: gynecomatia and amenorrhea |
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Estrogens
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bind estrogen receptors
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Use: hypogonadism, ovarian failure, menstrual abnormalitites, HRT for menopause, men with androgen dependent prostate cancer
Toxicity: increased risk of endometrial cancer, bleeding in postmenopausal women, clear cell adenocarcinoma of vagina (DES), increase risk of thrombi |
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clomiphene
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SERM, partial agonist at receptor in hhypothalamus to prevent feedbac inhibition
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Use: infertility and PCOS
Toxicity: hot flashes, ovarian enlargement multiple simultaneous pregnancies and visual disturbances |
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tamoxifen
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SERM antagonist on breat tissue
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use: treat and prevent recurrence of ER positive breast cancer
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raloxifene
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SERM, agonist on bone, recudes resoprtion of bone
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use: osteoporosis
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HRT
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used to relieve or prevent menopasal symptoms and osteoporosis
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may increase risk of endometrial cancer, add progesterone. may increase CV risk
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anastrozole/exemestae
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aromatase inhibitors
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post menopausal women with breast cancer
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progestins
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bind progesterone receptors and reduce growth and increase vascularization of endometrium
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use: oral contraceptives and treatment of endometrial cancer and abnormal uterine bleeding
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mifepristone
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competitive inhibitor of progestins at progesterone receptors
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use: termination of pregnancy (with misoprostol)
Toxicity: heavy bleeding, GI effects, abdominal pain |
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dinoprostone
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PGE2 analog causes cervical dilation and uterine contraction
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use: induce labor
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ritodrine/terbutaline
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beta 2 agonists that relax smooth muscles
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reduce prematre contraction
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tamsulosin
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alpha 1 antagonist
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used to treat BPH by inhibiting smooth muscle contraction, selective for alpha 1a,d receptors
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sidenafil, vardenafil
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inhibit phosphodiesterase, increases cGMP levels and smooth muscle relaxation in the corpus cavernosum
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use: ED
Toxicity: headache, flushing, dyspepsia, impaired blue-green color vision, lifethreatening hypotension with nitrates |
