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37 Cards in this Set
- Front
- Back
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Reproductive drugs therapeutic goals
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Enhance/manipulate normal cycling or pregnancy
Prevent normal cycling, prevent or terminate pregnancy Treat infertility |
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Hypothalmus endogenous hormones
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GnRH
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Pituitary endogenous hormones
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FSH
LH Prolactin Oxytocin |
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FSH
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females- follicle development
males - sperm maturation |
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LH
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females - follicle development, stimulates CL to secrete progesterone
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Prolactin
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stimulates postpartum lactation
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Oxytocin
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produced in hypothalmus
stored in pituitary uterin contraction and milk ejection |
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Uterus placenta hormones
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PGF2a
hCG eCG/PMSG |
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PGF2a
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helps regulate estrus cycle in ruminants
causes luteolysis and subsequent decreases in progesterone level |
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hCG
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LH like
induced ovulation |
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eCG/PMSG
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FSH-like, some LH
induce ovulation |
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ovary/Uterus/Testicles
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Progesterone
estrogen Testosterone |
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Progesterone
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helps regulate estrus cycle - hormone of pregnancy
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estrogen
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helps regulate estrous cycle
responsible for ovulation |
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Testosterone
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spermatogenesis
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GnRH drugs
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induce ovulation, intertility therapy
Gonadorelin |
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Gonadotropin drugs
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PG600
Prolactin Metoclopramide Domperidone |
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PG600
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hCG & eCG
induce ovulation, infertility therapy ADE: potential for Ab formation - inefficacy |
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Prolactin drug
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no therapeutic uses
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metoclopramide as repro drug
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prolactin enhancer - D antagonist
No oral admin |
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Domperidone
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prolactin enhancer
NO oral admin Does not cross BBB so no CNS effects ADE:premature lacation, undesirable prokinetic |
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Oxytocin
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induce parturition and milk letdown, enhance uterine contractions
ADE: after repated dosing - aggressive uterine contractions |
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Prostaglandins drugs
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PGF2a
Dinoprost Cloprostenol |
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PGFa
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induce parturition in sows and goats
will induce abortion in other species |
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Dinoprost
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PGFa analog
Used to synchronize estrus stimulate luteolysis stimulate parturition Pregnant women should not handle |
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Cloprostenol
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PGF2a analog
longer half life than dinoprost |
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Steroid repro drugs
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estrogen
Estradiol DES |
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Estradiol
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Illegal in food animals
ADE: bone marrow suppression - aplastic anemia, pyometria in dogs |
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DES
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prohibited in FAs b/c inc risk of vervical cancer in humans
used for spay incontinence in dogs sometimes ADE: human risks |
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Progestins
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Progesterone - CIDR
Altregonost Metengestrol acetate megestrol acetate Syncro-Mate |
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Progesterone
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CIDR
used to prevent or synchronize estrus vaginal insert approved in sheep, goats, cattle |
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Altregenost
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used to prevent or synchronize estrus in mare and pig approved in horses
ADE:high doses - fetal abnormalities |
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metengestrol acetate
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Used to prevent or synchronize estrus
Feed additive often used for feedlot heifres |
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Megestrol acetate
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Used to prevent or synchronize estru
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Syncro-Mate
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progsterone + estrogen
Used to prevent or sync estrus |
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Androgens
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Testosterone
Injectable regulates spermatogenesis neg feedback on gonadorelins/gonadotropins |
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Anabolic steroids
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stenozolol
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