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15 Cards in this Set
- Front
- Back
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The testes of gonadal males secrete?
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antimeullerian hormone and testosterone
AMH causes atrophy of meullerian ducts, which would have become the female internal genital tract |
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Without anti-meullerian hormone, the meullerian ducts are not suppressed and therefore......
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develop into the female internal genital tract
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This is the major androgen synthesized and secreted by the Leydig cells.
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Testosterone
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Because leydig cells do not have 21B-hydroxylase or 11B hydroxylase, they cannot synthesize......
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glucocorticoids/mineralcorticoids
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Leutenizing hormone increases testosterone synthesis by stimulating this substance( the first step in the pathway)
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cholesterol desmolase
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The prostate contains 5-alpha reductase which converts what......
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testosterone to dihydrotestosterone(active form)
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What is finasteride?
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It is a 5 alpha reductase inhibitor used to treat benign prostatic hypertrophy
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What do the Arcuate nuclei of the hypothalamus secrete?
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GnRH into the hypothalamic hypophysial portal blood. Stimulates ant pituitary to secrete FSH/LH
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Starting from Cholesterol, how is testosterone created?
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Cholesterol-pregnenolone-17-hydroxypregnenolone-dehydroepiandrosterone-androstenedione-testosterone-dihydrotestosterone
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FSH acts on which cells in the male?
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Sertoli cells to maintain spermatogenesis. These cells also secrete inhibin for negative feedback.
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LH acts on which cells in the male?
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Leydig cells to promote testosterone synthesis.
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Puberty in the male is iniated by....
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the onset of pulsatile GnRH release from the hypothalamus
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What can be said about the variation in FSH and LH levels over the life span of the male and female?
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Chilhood, hormone levels are lowest, FSH>LH
Puberty, hormone levels increase, LH>FSH senescence-hormone levels are highest, FSH>LH |
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Theca cells in the female produce.....
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Testosterone, at first step by LH. Testosterone diffuses to nearby granulosa cells which have aromatase and convert Testosterone to 17B- estradiol(stimulated by FSH)
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From cholesterol, what is the synthesis of estrogen?
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Cholesterol-pregnenolone-17-hydroxypregnenolone-dehydroepiandrosterone-androstenedione-testosterone-17B estradiol(requires aromatase)
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