Reproduction L17_Male_Reproductive_System

Front 1

How does male genitalia develop? (hint: Leydig cells, testosterone, hCG, and LH)

Back 1

How does male genitalia develop? Early fetus: hCG --> stimulates leydig cell production… @ 3 months: ↑LH --> stimulate leydig cells to produce testosterone --> masculinization of external genitalia

Front 2

What is the biochemical pathway of testosterone production and regulation? (hint: cAMP, LH, cholesterol/acetate, leydig cells, estrogen)

Back 2

What is the biochemical pathway of testosterone production and regulation? PRODUCTION: LH --> LH-® on Leydig cells --> cAMP activates steroidogenesis --> cholesterol/acetate precursors converted to testosterone… REGULATION: Testosteron --(converted to)--> E --> negative Feedback at hypothalamus-pitutiary--> ↓ LH

Front 3

Which enzyme is needed to convert pregnolone into 17-OH progesterone?

Back 3

Which enzyme is needed to convert pregnolone into 17-OH progesterone? 17∂ hydroxylase

Front 4

With Testerosterone as the precurosor --> X: Match the enzyme with the end product: Estradiol (Active metabolites), DHT (Active metabolites), 17-Ketosteroid (excretory metabolite), polar metabolite (excretory)…. Enzyme: 5∂ reductase, 17ßHSD, hydrolase conj enzyme, aromatase

Back 4

With Testerosterone as the precurosor --> X: Match the enzyme with the end product: (a) aromatase > Estradiol (Active metabolites), (b) 5∂ reductase> DHT (Active metabolites), (c) 17ßHSD > 17-Ketosteroid (excretory metabolite), (d) hydrolase conj enzyme > polar metabolite (excretory)Ketosteroid (excretory metabolite), polar metabolite (excretory)…. Enzyme: 5∂ reductase, 17ßHSD, hydrolase conj enzyme, aromatase

Front 5

Which are due to CNS effects of conversion of T-(aromatase)-> E and which are actions due to action of 5∂ reductase: secondary sex structures, erectile fx and libido

Back 5

(1) Erectile fx and libido are due to CNS effects of conversion of T-(aromatase)-> E… (2) secondary sex structures are due to actions of 5∂ reductase

Front 6

T/F: testosterone fx is based solely on testosterone itself.

Back 6

T/F: testosterone fx is based solely on testosterone itself FALSE

Front 7

T--> Estradiol has action on which of the following? Kidney, bone,bone marrow (RBCs), brain, genetalia, prostate, skin, hair follicles, muscle

Back 7

T--> Estradiol has action on which of the following? Bone and brain

Front 8

T--> Androstanediol has action on which of the following? Kidney, bone, bone marrow (RBCs), brain, genetalia, prostate, skin, hair follicles, muscle

Back 8

T--> Androstanediol has action on which of the following? Kidney, bone, bone marrow (RBCs)

Front 9

T--> DHT has action on which of the following? Kidney, bone, bone marrow (RBCs), brain, genetalia, prostate, skin, hair follicles, muscle

Back 9

T--> DHT has action on which of the following? genetalia, prostate, skin, hair follicles

Front 10

Testosterone itself has action on which of the following? Kidney, bone, bone marrow (RBCs), brain, genetalia, prostate, skin, hair follicles, muscle

Back 10

Testosterone has action on which of the following? muscle

Front 11

Which of the following is true about the effects of Testosterone (whether as testosterone or a metabolite)? Synergistic growth in association with GH, increased RBCs, Liver: increased SHBG, increased HDL, decreased Libido, increased muscle mass and strength, fat distribution to intra-abdominal area

Back 11

Which of the following is true about the effects of Testosterone (whether as testosterone or a metabolite)? TRUE: Synergistic growth in association with GH, increased RBCs, increased muscle mass and strength, fat distribution to intra-abdominal area… FALSE: T --> Liver: DECREASED SHBG NOT increased, & T--> LIver --> decreased HDL, INCREASED Libido NOT decrease

Front 12

Why does system testosterone cause infertility?

Back 12

Why does system testosterone cause infertility? Large amounts of Testosterone produced Leydig cells locally increases testosterone, which is needed for spermatogenesis… HOWEVER, SYSTEMICALLY : ↑ T --> E --> ↓ LH secretion --> ↓ stimulation at leydig cells --> ↓ testosterone production at leydig cells

Front 13

Which of the following are NOT true about spermatogenesis: (1) requires 1-2°C higher temp than intra abdominal temp, (2) requires adequate O2, (3) accounts for 66% of testicular volume.

Back 13

Which of the following are NOT true about spermatogenesis: TRUE: (2) requires adequate O2, (3) accounts for 66% of testicular volume… FALSE: (1) requires 1-2°C LOWER NOT higher temp than intra abdominal temp,

Front 14

Which cells is needed for (1) support germ cells, (2) production of blood-testis-barrier? Leydig cells or Sertoli cells

Back 14

Which cells is needed for (1) support germ cells, (2) production of blood-testis-barrier? Sertoli cells

Front 15

Which cell produces the following: androgen binding protein, transferin, inhibin, proteoglycans, and estrodiol?

Back 15

Which cell produces the following: androgen binding protein, transferin, inhibin, proteoglycans, and estrodiol? Sertoli cells

Front 16

What role do Transferin and Inhibin (produced in sertoli cells) play

Back 16

Produced in sertoli cells: Inhibin controls FSH production… Transferin pulls iron into the tubules

Front 17

Which cells make factors (cytokines) and what the role of these factors?

Back 17

Interstial cells make factors, which control both the sertoli and leydig cells

Front 18

Which cells make a tight junction between themselves that serves as a blood-testis barrier?

Back 18

Which cells make a tight junction between themselves that serves as a blood-testis barrier? Sertoli cells

Front 19

What is required for spermatogenesis and how many days does it take for spermatogenesis to occur?

Back 19

What is required for spermatogenesis: T and FSH… How many days does it take for spermatogenesis to occur? 74.5 days

Front 20

What are the exact roles of T and FSH in spermatogenesis?

Back 20

In spermatogenesis FSH initiates... T: maintains spermatogenesis

Front 21

What is the semen base (N) values for count, motility, volume, normal forms?

Back 21

Semen Analysis: (N) values for count>20 million/mL, motility= >50%, volume=2-5 mL, normal forms > 70%?

Front 22

What would you expect levels of LH, FSH and T to be in Kallman's in boys?

Back 22

What would you expect levels of LH, FSH and T to be in Kallman's in boys? All would be suppressed

Front 23

Would other pituitary fx be normal in Kallmann's syndrome?

Back 23

Would other pituitary fx be normal in Kallmann's syndrome? Yes

Front 24

In Klinefelter's syndrome, what would you expect the lab finding for : FSH, LH, Testosterone, and prolactin?

Back 24

In Klinefelter's syndrome, what would you expect the lab finding for : ELEVEATED: FSH, LH, and prolactin… LOW: Testosteron

Front 25

What is the karyotype in Klinefelters? And what happens to the testis?

Back 25

What is the karyotype in Klinefelters? 47 XXY… And what happens to the testis? Low volume

Front 26

What is the Rx for Klinefelters?

Back 26

Testosterone derivative, e.g., methyl T (oral doses)