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26 Cards in this Set
- Front
- Back
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This develops primarily from medulla while this develops from the cortex
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testis - medulla
ovary - cortex |
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Both of these ducts are present in the undifferentiated embryo. Which is in females? Males?
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Muellerian ducts - females
Wolffian ducts - males |
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The differentiation of male genitalia requires this enzyme?
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5 a-reductase
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Without this, external genitalia become female regardless of sexual genotype?
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Dihydrotestosterone
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When does gonadal differentiation occur?
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Weeks 6-8
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This stimulates the develop of the testis?
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The SRY which encodes for TDF
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What does testis determining factor produce?
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The seminiferous tubules
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What sexs produce MIF?
What is the action of MIF? |
Sertoli cells; inhibits development of the Muellerin ducts
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What stimulates the development of the Wolffian duct?
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Testosterone
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What is the fxn of dihydrotestosterone?
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It creates the external genitalia: penis, penile urethra, and scrotum
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What creates female genitalia?
What is inessential in creating female genitalia? |
The absence of DHT.
Estradiol is not essential. |
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What is the purpose of estradiol?
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Clitoris, labia minora, labia majora, and lower vagina formation
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The Muellerian ducts help to form what stx's?
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uterus, fallopian tube, and the upper vagina
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CAH is caused by what?
What increases? |
21 and 11 hydroxylase deficiency necessary for cortisol production; adrenal androgens and corticosteroid precursors
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Explain gonadal dysgenesis?
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Is incomplete differentiation of the gonads due to errors in meiosis. (Klinefelter's or Turner's)
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What is true hermophrodism?
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One has ovaries and testes
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What is pseudohermophrodism?
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One type of gonad but different external differentation. (CAH or 5 a-reductase deficiency)
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What happens in the case of 5 a-reductase insufficiency?
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Female genitalia develop
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What type of gonads are present in a Turner individual? How do the external genitals appear?
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Streaked ovaries. Female
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With the loss of a gene for the androgen receptor, what is the outcome of the Wolffian duct?
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regression.
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What is the outcome of the Wolffian duct in a XY 5 a-reductase deficient male?
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development
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In an XX female with CAH, how do the external genitalia appear?
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Male?
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How do the gonads of an XY testosterone deficient person appear?
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Male
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What are the external genitalia of an XY testosterone deficient person?
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Female (variable)
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How do the external genitalia of an XY 5 a-reductase deficient person appear?
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Female (variable)
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What type of epithelium develops into testis and the ovaries?
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germinal epithelium
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