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29 Cards in this Set

  • Front
  • Back
What is the screening tool for cervical cancer?
Pap Smear
The cervix is located at what portion of the uterus?
Inferior extension
In development, what type of cells line the uterivaginal canal
Columnar epithelium
What is the Original Transformation zone?
The point where columnar and squamous cells meet
Where is theOriginal transformation zone located
At the endocervical canal
At what point are cells vulnerable to neplasm
When columnar cells convert to squamous cells
At reproductive stage where is the SCJ located
It moves out of the endocervical canal
Why does columnar cell change to squamous cells when they move out of the endocervical canal
Because they get exposed to the Vaginal acid
What is the transformations zone
Its the zone b/w the original SCj and the new SCJ
What are the 2 types pf cytologic specimens for PAP smear
1) conventional PAP
2) Liquid based PAP (more accurate)
Squamous intraepitheial adnrmalies are associted with what?
How does one get Mild dysplasia after exposure to HPV
produces proteins that direct the host cell to undergo maturation and cell death. Cells exfoliate, disintegrates and release large numbers of intact viral particles. (DNA has not gotten into the genome)
**80% of pts with mild dysplasia go back to normal**
How does one get Moderate and severe dysplasia after exposure to HPV
• Moderate dysplasia and severe dysplasia, there is an actual disruption of the HPV DNA and it is integrated into the host cell genome. Results in transformation and proliferation of the immature basal or parabasal cells. (DNA is more incorporated)
What kind of dysplasia covers 2/3 of the epithelial surface
What kind of dysplasia covers the entire epithelial surface but stops at the basal layer
Exposure to what is necessary for development of cervical neoplasm
Genital warts are related to what strains of HPV
What strainsa re covered by the gardisil vaccine
What are cellular changes defines as?
• Cellular changes are reactive and reparative secondary to life events (tampons, intercourse, BV, yeast, aging and decreased estrogen). Give Gradual Estrogen for a week and then repeat pap smear.
WHen do you begin perfrming PAP smears?
• Begin screening 3 yrs. after the onset of vaginal intercourse and no later than 21yrs.
• Screening done annually until the age of 30. If there are 3 normal PAP’s in a row, may go to every 2–3yrs.
If a pts report states that they have mild dysplasia, what should you next step be?
Colposcopy with biopsy
Do you need to do colposcpy and Biopsy together for ASCUS
If you do a biopsy for the pt who had mild grade dyplasia and find that they have LSIL, what do you do next
• If biopsy confirms LSIL, two options:
1. Follow with PAP every 4-6 months. When three consecutive normal PAP can go to annually.
2. Treatment with cryosurgery (freeze cervix), laser ablation(laser dessicates abnormal part) or excision (laser cuts abnormal part), LEEP (Loop Electrosurgical Excision Procedure-cuts abnormal parts off), CKC (Cold Knife Conization), then follow up PAP’s.
If you do a biopsy for the pt who had mild grade dyplasia and find that they have HSIL, what do you do next
• Colposcopy with endocervical biopsies.
• Biopsies need to match.
How would you trest carcinoma in sity
What should be your next step in the following cases:
1) If invasive disease,
2) If no invasive disease and AGC NOS, no abnormal pathology,
3) If no invasive disease AGC NOS and biopsy is CIN or AIS, 4) If no invasive disease and AGC favors dysplasi
1) refer to the GYN/ONC.
2) can go to PAP every 4-6 months until 3 consecutive normal.
3) excisional biopsy is indicated.
4) next step is a Cold Knife Conization
Which procedure is safe to do in a pregnant woment to screen for abnormalities
Colposcopy with exctocervical biopsy if indicated.
Which procedure is NOT safe to do in a pregnant woment to screen for abnormalities
Endocervical Biopsy- it can disturb the pregnancy
You should ALWAYS do what test before doing any colposcopy procedure
ALWAYS do a pregnancy test prior to a colposcopy.