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22 Cards in this Set

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What determines the cycle length?
Day 1 of bright red bleeding to the next time of bright red bleeding

Average is is 28 days
21-35 still within normal limits
What defines oligo and hypermenorrhea?
Oligomenorrhea > 35 day cycles
Hypermenorrhea < 21 day cycles
biggest cause of oligomenorrhea? others? tx?
biggest: anovulation

others:
Extremes of age – teens and perimenopause

Tx:
Oral contraceptives
Cyclic progestins (trick the body into thinking it is in withdrawal)
What problem can hypothyroidism cause with respect to a woman's cycle? what is important to remember about the tx?
oligomenorrhea

Treat with thyroid hormone – clinical response won't show up for 6 – 8 weeks
What problem can hyperthyroidism cause with respect to a woman's cycle?
Oligomenorrhea or hypermenorrhea
pt has amenorrhea that is attributed to a prolactinoma...what do you do for tx? (there are 2 things to consider here)

ALSO; this had **** on her slide, but she didn't even mention it
TSH can be elevated... so one tx:
****Treat hypothyroidism if TSH is elevated


****Treat with bromocriptine if isolated ^prolactin
What effects can anorexia and obesity have on cycles?
Anorexia: Period loss

Obesity: Lots of estrogen, gets converted to testosterone-->leads to Polycystic Ovarian Syndrome
An overweight woman comes to the office with oligomenorrhea, acne, and hirsuitism. She comes in because she is having difficulty getting pregnant. What should you start thinking?
Polycystic Ovarian Syndrome

Note: this can also be in normal weight women
Rosary beads/String of pearls=

(she said this is common for boards, not in real life, or really important for her)
cysts arrested in development that line the peripheral of the ovary

POLYCYSTIC OVARIAN SYNDROME
27 year old woman trying to get pregnant has oligomenorrhea. You do an ultrasound and see slight endometrial proliferation. Why should you get a biopsy?
this is POLYCYSTIC OVARIAN SYNDROME

it can lead to ENDOMETRIAL CANCER
What role does insulin resistance play in PCOS?
Insulin like growth factor abnormally stimulates an already overestrogenized endometrium – furthers endometrial cancer risk
Weight loss can help increase ovulation, how much do you need to lose do this?
only 10%
Major tx for PCOS?
Oral contraceptives

Increase SHBG – decrease free testosterone
Improves acne, hair growth, male pattern balding
Empties uterus monthly – may reduce long term risk of endometrial cancer
This drug increases insulin sensitivity and thus can be used as a tx for PCOS. What is the drug? What is a possible side-effect that can be beneficial?
Metformin

May aid in weight loss- they will poop their brains out
What is Ovarian drilling?
allows for rupture and release of follicles by poking holes into the ovary

you do this when you see the rosary beads/pearls pattern (PCOS)
What is the difference between dysfunctional and abnormal bleeding?

****COMMON PIMP QUESTION: TEST CITY
Dysfunctional uterine bleeding – physiological dysfunction (anovulation)

Abnormal uterine bleeding – anatomical abnormality (think like a polyp on the uterus or fibroids)
Most common reason of Abnormal uterine bleeding?
FIBROID

remember, AUB is due to anatomical abnormality while DUB is due to physiological bleeding....aka this is AUB
what are the common presentations for:

Endometrial cancer?
Cervical cancer?

(I don't think these will be on the test, but who knows)
Endometrial Cancer – postmenopausal bleeding

Cervical Cancer – postcoital bleeding

note to remember:
Endometrial Hyperplasia – precancerous
What are some of the tx options for DUB?
OCP’s

Cyclic progestins

Continuous progestins – includes Depo Provera (she HATES this drug, tons of side effects), Mirena IUD (she LIKES this drug but it can be expensive and have side effects)
you suspect a pt has DUB so you start her on an OCP. She comes back later and is still bleeding, what is going on?

***STARRED ON SLIDE
****If the bleeding is due to an anatomical cause, it won’t respond.

so she likely has a fibroid or polyp or some ANATOMICAL cause (AUB)
What is Dilation and Curettage?

possible adverse effect?
Scrape endometrium--Diagnostic test

DOES NOT TREAT ABNORMAL BLEEDING

Adverse effect:
Asherman’s Syndrome – amenorrhea, uterine synechiae, infertility (get tons of scarring, looks like spiderwebs, can't get preggo)
what treatment can help reduce flow in up to 80% of biddies?
Endometrial ablation